About: Protection against Amoebic Liver Abscess in Hamster by Intramuscular Immunization with an Autographa californica Baculovirus Driving the Expression of the Gal-Lectin LC3 Fragment

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About: Protection against Amoebic Liver Abscess in Hamster by Intramuscular Immunization with an Autographa californica Baculovirus Driving the Expression of the Gal-Lectin LC3 Fragment Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protection against Amoebic Liver Abscess in Hamster by Intramuscular Immunization with an Autographa californica Baculovirus Driving the Expression of the Gal-Lectin LC3 Fragment
Creator	Aguilar-Diaz, Hugo Sampieri, Alicia Vaca, Luis Bobes, Raúl Carrero, Julio Laclette, Juan Meneses-Ruiz, Dulce
Source	PMC
abstract	In a previous study, we demonstrated that oral immunization using Autographa californica baculovirus driving the expression of the Gal-lectin LC3 fragment (AcNPV-LC3) of Entamoeba histolytica conferred protection against ALA development in hamsters. In this study, we determined the ability of AcNPV-LC3 to protect against ALA by the intramuscular route as well as the liver immune response associated with protection. Results showed that 55% of hamsters IM immunized with AcNPV-LC3 showed sterile protection against ALA, whereas other 20% showed reduction in the size and extent of abscesses, resulting in some protection in 75% of animals compared to the sham control group. Levels of protection showed a linear correlation with the development and intensity of specific antiamoeba cellular and humoral responses, evaluated in serum and spleen of hamsters, respectively. Evaluation of the Th1/Th2 cytokine patterns expressed in the liver of hamsters showed that sterile protection was associated with the production of high levels of IFNγ and IL-4. These results suggest that the baculovirus system is equally efficient by the intramuscular as well as the oral routes for ALA protection and that the Gal-lectin LC3 fragment is a highly protective antigen against hepatic amoebiasis through the local induction of IFNγ and IL-4.
has issue date	2015-05-19(xsd:dateTime)
bibo:doi	10.1155/2015/760598
bibo:pmid	26090442
has license	cc-by
sha1sum (hex)	7870870602f0a4edb3a7ea468659e2eb23cb2202
schema:url	https://doi.org/10.1155/2015/760598
resource representing a document's title	Protection against Amoebic Liver Abscess in Hamster by Intramuscular Immunization with an Autographa californica Baculovirus Driving the Expression of the Gal-Lectin LC3 Fragment
has PubMed Central identifier	PMC4452260
has PubMed identifier	26090442
schema:publication	Biomed Res Int
resource representing a document's body	covid:7870870602f0a4edb3a7ea468659e2eb23cb2202#body_text
is schema:about of	named entity 'PROTECTION' named entity 'INTRAMUSCULAR' named entity 'ability' named entity 'Th1' named entity 'driving' named entity 'linear correlation' named entity 'control group' named entity 'liver' named entity 'oral' named entity 'abscesses' named entity 'Intramuscular' named entity 'DRIVING' named entity 'AMOEBIC LIVER ABSCESS' named entity 'LECTIN' named entity 'INTENSITY' named entity 'ASSOCIATED WITH' covid:arg/7870870602f0a4edb3a7ea468659e2eb23cb2202 named entity 'DEVELOPMENT' named entity 'PATTERNS' named entity 'HIGH' named entity 'INDUCTION' named entity 'PRODUCTION' named entity 'AUTOGRAPHA CALIFORNICA' named entity 'STERILE' named entity 'ORAL IMMUNIZATION' named entity 'FRAGMENT' named entity 'HAMSTERS' named entity 'DETERMINED' named entity 'IMMUNIZATION' named entity 'PREVIOUS' named entity 'ANIMALS' named entity 'PROTECTION' named entity 'HEPATIC AMOEBIASIS' named entity 'REDUCTION' named entity 'IMMUNIZED' named entity 'BACULOVIRUS' named entity 'FRAGMENT' named entity 'RESULTS' named entity 'RESPONSES' named entity 'INTRAMUSCULAR ROUTE' named entity '20%' named entity 'COMPARED' named entity 'STUDY' named entity 'EXTENT OF' named entity 'LC3' named entity 'RESULTING IN' named entity 'SYSTEM' named entity 'EXPRESSION' named entity 'HAMSTER' named entity 'GAL' named entity 'LC3' named entity 'CELLULAR' named entity 'IMMUNE RESPONSE' named entity 'PROTECTIVE ANTIGEN ' named entity 'ABSCESSES' named entity 'LIVER' named entity 'SHAM CONTROL GROUP' named entity 'SIZE' named entity 'ALA' named entity 'ENTAMOEBA HISTOLYTICA' named entity 'TH1' named entity 'BACULOVIRUS' named entity 'GAL' named entity 'EXPRESSION' named entity 'DRIVING' named entity 'EVALUATION' named entity 'EFFICIENT' named entity 'ORAL' named entity 'INTRAMUSCULAR' named entity 'ABILITY' named entity 'IS A' named entity 'LINEAR' named entity 'CORRELATION' named entity 'LEVELS' named entity 'SPLEEN'

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