About: Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19

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About: Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19
Creator	Alcaraz-Serna, Ana Alfranca, Arantzazu Assistant, Calzada, María Del Campo Guerola, Luciana Esparcia, Laura Gabrie, Ligia González-Álvaro, Isidoro López-Sanz, Celia Marcos-Jiménez, Ana Martín-Gayo, Enrique Martínez-Fleta, Pedro Mateu-Albero, Tamara Muñoz-Calleja, Cecilia Soriano, Joan Sánchez-Madrid, Francisco Sánchez-Alonso, Santiago Sánchez-Cerrillo, Ildefonso Ancochea, Julio Aldave, Beatriz Azofra, Ana De Los Santos, Ignacio Martin-Gayo, Enrique
Source	MedRxiv; Medline
abstract	The SARS-CoV-2 is responsible for the pandemic COVID-19 in infected individuals, who can either exhibit mild symptoms or progress towards a life-threatening acute respiratory distress syndrome (ARDS). It is known that exacerbated inflammation and dysregulated immune responses involving T and myeloid cells occur in COVID-19 patients with severe clinical progression. However, the differential contribution of specific subsets of dendritic cells and monocytes to ARDS is still poorly understood. In addition, the role of CD8+ T cells present in the lung of COVID-19 patients and relevant for viral control has not been characterized. With the aim to improve the knowledge in this area, we developed a cross-sectional study, in which we have studied the frequencies and activation profiles of dendritic cells and monocytes present in the blood of COVID-19 patients with different clinical severity in comparison with healthy control individuals. Furthermore, these subpopulations and their association with antiviral effector CD8+ T cell subsets were also characterized in lung infiltrates from critical COVID-19 patients. Collectively, our results suggest that inflammatory transitional and non-classical monocytes preferentially migrate from blood to lungs in patients with severe COVID-19. CD1c+ conventional dendritic cells also followed this pattern, whereas CD141+ conventional and CD123hi plasmacytoid dendritic cells were depleted from blood but were absent in the lungs. Thus, this study increases the knowledge on the pathogenesis of COVID-19 disease and could be useful for the design of therapeutic strategies to fight SARS-CoV-2 infection.
has issue date	2020-05-16(xsd:dateTime)
bibo:doi	10.1101/2020.05.13.20100925
bibo:pmid	32511573
has license	medrxiv
sha1sum (hex)	77931cd0a42bbcc8c27bac94576a9a9a1dda5c0d
schema:url	https://doi.org/10.1101/2020.05.13.20100925
resource representing a document's title	Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19
has PubMed identifier	32511573
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:77931cd0a42bbcc8c27bac94576a9a9a1dda5c0d#body_text
is schema:about of	named entity 'EXHIBIT' named entity 'CRITICAL' named entity 'COVID-19' named entity 'ADDITION' named entity 'CHARACTERIZED' named entity 'LUNG INFILTRATES' named entity 'HAVE' named entity 'ROLE' named entity 'CONTROL' named entity 'PANDEMIC' named entity 'ARDS' named entity 'immune responses' named entity 'COVID' named entity 'life-threatening' named entity 'COVID' named entity 'Dendritic Cell' named entity 'inflammatory' named entity 'pDC' named entity 'COVID' named entity 'CD40' named entity 'effector' named entity 'tSNE' named entity 'early diagnosis' named entity 'CD8 +' named entity 'COVID' named entity 'peer review' named entity 'peripheral blood' named entity 'myeloid cells' named entity 'CD38' named entity 'CD40' named entity 'flow cytometry' named entity 'clinical outcomes' named entity 'RNA' named entity 'sodium chloride' named entity 'CD4 +' named entity 'aspirating' named entity 'COVID-19 disease' named entity 'serum' named entity 'pDC' named entity 'CRP' named entity 'antibacterial' named entity 'COVID' named entity 'IL-6' named entity 'bronchoscopy' named entity 'COVID-19 disease' named entity 'medRxiv' named entity 'medRxiv' named entity 'inflammatory markers' named entity 'medRxiv' named entity 'p<0.01' named entity 'effector' named entity 'peripheral blood' named entity 'CD8 +' named entity 'peer review' named entity 'CRP' named entity 'antiviral' named entity 'lung tissue' named entity 'tSNE' named entity 'CD14' named entity 'IL-6'

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