About: Escape From Monoclonal Antibody Neutralization Affects Henipavirus Fitness In Vitro and In Vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Escape From Monoclonal Antibody Neutralization Affects Henipavirus Fitness In Vitro and In Vivo
Creator	Borisevich, Viktoriya Feldmann, Heinz Lee, Benhur Rockx, Barry Hickey, Andrew Broder, Christopher Debuysscher, Blair
Source	Medline; PMC
abstract	Henipaviruses are zoonotic viruses that can cause severe and acute respiratory diseases and encephalitis in humans. To date, no vaccine or treatments are approved for human use. The presence of neutralizing antibodies is a strong correlate of protection against lethal disease in animals. However, since RNA viruses are prone to high mutation rates, the possibility that these viruses will escape neutralization remains a potential concern. In the present study, we generated neutralization-escape mutants, using 6 different monoclonal antibodies, and studied the effect of these neutralization-escape mutations on in vitro and in vivo fitness. These data provide a mechanism for overcoming neutralization escape by use of cocktails of cross-neutralizing monoclonal antibodies that recognize residues within the glycoprotein that are important for virus replication and virulence.
has issue date	2015-09-10(xsd:dateTime)
bibo:doi	10.1093/infdis/jiv449
bibo:pmid	26357909
has license	bronze-oa
sha1sum (hex)	777221f31bf2b3457f7d81bb9abe03a179fb3fa9
schema:url	https://doi.org/10.1093/infdis/jiv449
resource representing a document's title	Escape From Monoclonal Antibody Neutralization Affects Henipavirus Fitness In Vitro and In Vivo
has PubMed Central identifier	PMC4704671
has PubMed identifier	26357909
schema:publication	Journal of Infectious Diseases
resource representing a document's body	covid:777221f31bf2b3457f7d81bb9abe03a179fb3fa9#body_text
is schema:about of	named entity 'vivo' named entity 'escape' named entity 'possibility' named entity 'RNA' named entity 'human' named entity 'MONOCLONAL ANTIBODY' named entity 'IN VITRO' named entity 'HENIPAVIRUS' named entity 'FITNESS' named entity 'ACUTE' named entity 'PROTECTION' named entity 'POTENTIAL' named entity 'DATA' named entity 'MUTATIONS' named entity 'CROSS' named entity 'RESPIRATORY DISEASES' named entity 'IN VIVO' named entity 'IN VITRO' named entity 'PRESENT' named entity 'HENIPAVIRUSES' named entity 'VIRULENCE' named entity 'RNA VIRUSES' named entity 'PRESENCE OF' named entity 'POSSIBILITY' named entity 'ESCAPE' named entity 'STUDY' named entity 'IMPORTANT' named entity 'MUTATION RATES' named entity 'RECOGNIZE' named entity 'MUTANTS' named entity 'HIGH' named entity 'PRONE' named entity 'CAUSE' named entity 'VACCINE' named entity 'DIFFERENT' named entity 'MECHANISM' named entity 'NEUTRALIZING ANTIBODIES' named entity 'JOURNAL ' named entity 'ZOONOTIC' named entity 'EFFECT' named entity 'IN VIVO' named entity 'ESCAPE' named entity 'HUMANS' named entity 'VIRUS REPLICATION' named entity 'LETHAL' named entity 'INFECTIOUS DISEASES' named entity 'USING' named entity 'GLYCOPROTEIN' named entity 'FITNESS' named entity 'DATE' named entity 'MONOCLONAL ANTIBODIES' named entity 'GENERATED' named entity 'IS A' named entity 'ENCEPHALITIS' named entity 'COCKTAILS' named entity 'HUMAN USE' named entity 'STRONG' named entity 'PROVIDE' named entity 'APPROVED' named entity 'USE OF' named entity 'THESE' named entity 'VIRUSES' named entity 'ANIMALS' named entity 'DISEASE' named entity 'TREATMENTS' named entity 'SEVERE' named entity 'CONCERN' covid:arg/777221f31bf2b3457f7d81bb9abe03a179fb3fa9 named entity 'severe' named entity 'mutants' named entity 'escape' named entity 'cocktails' named entity 'viruses' named entity 'vaccine' named entity 'Infectious Diseases'

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