About: Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study

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About: Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study
Creator	Checkley, William Herrera, Phabiola Hossen, Shakir Gupta, Ena Brower, Roy Chirinos, Eduardo Grigsby, Matthew Jaymez, Amador Paz, Enrique Portugal, Jose Quispe, Rocio Roldan, Rollin
Source	PMC
abstract	BACKGROUND: Clinical and epidemiological differences between acute respiratory distress syndrome (ARDS) that presents at the initiation of mechanical ventilation [MV] (ARDS at MV onset) and that which develops during the course of MV (ARDS after MV onset) are not well understood. We conducted an observational study in five Peruvian ICUs to characterize differences between ARDS at MV onset and after MV onset and identify risk factors for the development of ARDS after MV onset. METHODS: We consecutively enrolled critically ill patients with acute respiratory failure requiring at least 24 h of mechanical ventilation and followed them prospectively during the first 28 days and compared baseline characteristics and clinical outcomes by ARDS status. RESULTS: We enrolled 1657 participants on MV (mean age 60.0 years, 55% males) of whom 334 (20.2%) had ARDS at MV onset and 180 (10.9%) developed ARDS after MV onset. Average tidal volume at the initiation of MV was 8.7 mL/kg of predicted body weight (PBW) for participants with ARDS at MV onset, 8.6 mL/kg PBW for those who developed ARDS after MV onset, and 8.5 mL/kg PBW for those who never developed ARDS (p = 0.23). Overall, 90-day mortality was 56% and 55% for ARDS after MV onset and ARDS at MV onset, respectively, as compared to 46% among those who never developed ARDS (p < 0.01). Adults with ARDS had a higher body mass index (BMI) than those without ARDS (27.3 vs 26.5 kg/m(2), p < 0.01). Higher peak pressure (adjusted interquartile OR = 1.51, 95% CI 1.21–1.88), higher mean airway pressure (adjusted interquartile OR = 1.41, 95% CI 1.13–1.76), and higher positive end-expiratory pressure (adjusted interquartile OR = 1.29, 95% CI 1.10–1.50) at MV onset were associated with a higher odds of developing ARDS after MV onset. CONCLUSIONS: In this study of mechanically ventilated patients, 31% of study participants had ARDS at some point during their ICU stay. Optimal lung-protective ventilation was not used in a majority of patients. Patients with ARDS after MV onset had a similar 90-day mortality as those with ARDS at MV onset. Higher airway pressures at MV onset, higher PEEP, and higher BMI were associated with the development of ARDS after MV onset.
has issue date	2019-12-06(xsd:dateTime)
bibo:doi	10.1186/s13054-019-2646-8
bibo:pmid	31810487
has license	cc-by
sha1sum (hex)	772046ceb62525b9f5c685e2d2b8dd33573107ba
schema:url	https://doi.org/10.1186/s13054-019-2646-8
resource representing a document's title	Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study
has PubMed Central identifier	PMC6898929
has PubMed identifier	31810487
schema:publication	Crit Care
resource representing a document's body	covid:772046ceb62525b9f5c685e2d2b8dd33573107ba#body_text
is schema:about of	named entity 'develops' named entity 'observational study' named entity 'conducted' named entity 'onset' named entity 'Peru' named entity 'ARDS' named entity 'mechanically ventilated' named entity 'ARDS' named entity 'ARDS' named entity 'ARDS' named entity 'mechanical ventilation' named entity 'mechanically ventilated' named entity 'Risk factors' named entity 'APACHE III' named entity 'mechanical ventilation' named entity 'ARDS' named entity 'BMI' named entity 'plateau pressure' named entity 'ARDS' named entity 'pulmonary edema' named entity 'heterogeneity' named entity 'ARDS' named entity 'ICU' named entity 'mechanical ventilation' named entity 'critical care' named entity 'ventilator-induced lung injury' named entity 'mechanical ventilation' named entity 'ICUs' named entity 'ARDS' named entity 'mechanical ventilation' named entity 'adhesion molecules' named entity 'ICUs' named entity 'mechanically ventilated' named entity 'arterial blood gases' named entity 'ARDS' named entity 'ARDS' named entity 'Fisher' named entity 'ARDS' named entity 'positive end-expiratory pressure' named entity 'Berlin' named entity 'ARDS' named entity 'molecular mechanisms' named entity 'tidal volume' named entity 'body mass index' named entity 'mechanical ventilation' named entity 'mechanical ventilation' named entity 'high-risk' named entity 'ICU' named entity 'ICU' named entity 'ICU' named entity '0.01' named entity 'respiratory failure' named entity 'ICU' named entity 'ARDS' named entity 'ARDS' named entity 'tidal volume' named entity 'animal studies' named entity 'mechanical ventilation' named entity 'mechanical ventilation' named entity 'mechanical ventilation' named entity 'PEEP' named entity 'ARDS' named entity 'ARDS' named entity 'APACHE III' named entity 'Stata' named entity 'mechanical ventilation' named entity 'bronchoconstriction' named entity 'ARDS' named entity 'mortality rates' named entity 'mechanical ventilation'

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