About: EWI‐2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry

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About: EWI‐2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	EWI‐2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry
Creator	Dubuisson, Jean Montpellier, Claire Cocquerel, Laurence Popescu, Costin-Ioan Baumert, Thomas Tews, Birke Couturier, Cyril Kaestner, Laura Milhiet, Pierre-Emmanuel Potel, Julie Rassam, Patrice Rubinstein, Eric Werkmeister, Elisabeth
topic	covid:771cd029ca09797f35f8525279aca10b87520947#this
Source	Medline; PMC
abstract	CD81 is a major receptor for Hepatitis C Virus (HCV). It belongs to the tetraspanin family whose members form dynamic clusters with numerous partner proteins and with one another, forming tetraspanin‐enriched areas in the plasma membrane. In our study, we combined single‐molecule microscopy and biochemistry experiments to investigate the clustering and membrane behaviour of CD81 in the context of cells expressing EWI‐2wint, a natural inhibitor of HCV entry. Interestingly, we found that EWI‐2wint reduces the global diffusion of CD81 molecules due to a decrease of the diffusion rate of mobile CD81molecules and an increase in the proportion of confined molecules. Indeed, we demonstrated that EWI‐2wint promotes CD81 clustering and confinement in CD81‐enriched areas. In addition, we showed that EWI‐2wint influences the colocalization of CD81 with Claudin‐1 – a co‐receptor required for HCV entry. Together, our results indicate that a change in membrane partitioning of CD81 occurs in the presence of EWI‐2wint. This study gives new insights on the mechanism by which HCV enters into its target cells, namely by exploiting the dynamic properties of CD81.
has issue date	2013-02-16(xsd:dateTime)
bibo:doi	10.1111/cmi.12112
bibo:pmid	23351194
has license	no-cc
sha1sum (hex)	771cd029ca09797f35f8525279aca10b87520947
schema:url	https://doi.org/10.1111/cmi.12112
resource representing a document's title	EWI‐2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry
has PubMed Central identifier	PMC7162402
has PubMed identifier	23351194
schema:publication	Cell Microbiol
resource representing a document's body	covid:771cd029ca09797f35f8525279aca10b87520947#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/771cd029ca09797f35f8525279aca10b87520947
is schema:about of	named entity 'insights' named entity 'plasma membrane' named entity '2012' named entity 'inhibitor' named entity 'clustering' named entity 'membrane' named entity 'confinement' named entity 'proteins' named entity 'belongs' named entity 'EWI' named entity 'exploiting' named entity 'clusters' named entity 'diffusion' named entity 'areas' named entity 'partitioning' named entity 'molecules' named entity 'members' named entity 'EWI' named entity 'single-molecule microscopy' named entity 'biochemistry' named entity 'tetraspanin' named entity 'EWI' named entity 'CD81' named entity 'HCV' named entity 'plasma membrane' named entity 'CD81' named entity 'CD81' named entity 'Claudin-1' named entity 'EWI' named entity 'CD46' named entity 'EWI' named entity 'TEMs' named entity 'Pileri' named entity 'EWI' named entity 'EWI' named entity 'immunoprecipitation' named entity 'CD81' named entity 'dimers' named entity 'Invitrogen' named entity 'Lysates' named entity 'life cycle' named entity 'lysates' named entity 'HCV' named entity 'HCV' named entity 'CD81' named entity 'CD81' named entity 'EWI' named entity 'EWI' named entity 'fatty acid' named entity 'TM4' named entity 'Espenel' named entity 'cytosolic' named entity 'receptor tyrosine kinases' named entity 'infection' named entity 'Montpellier' named entity 'EWI' named entity 'SDS-PAGE' named entity 'HCV' named entity 'EWI' named entity 'infectious diseases' named entity 'antibody' named entity 'CD81' named entity 'infection' named entity 'cysteine' named entity 'PBS' named entity 'HCV' named entity 'EWI'

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