About: Impact of community respiratory viral infections in urban children with asthma

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Impact of community respiratory viral infections in urban children with asthma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact of community respiratory viral infections in urban children with asthma
Creator	Xmd, X Xphd, X Batterman, Xstuart Brennan, Xsean Comstock, T Eder, Xbreanna Goldsmith, Xadam Hershenson, Xmarc Lewis, C Mentz, Xgraciela Metitiri, Xediri Mukherjee, X Owensd, B Ren, Xxiaodan Ricci, M Robins, G Walsh, P Washingtond, L Wicklund, E Xadam, X Xba, X Xbs, X Xginger, X Xjeannette, X Xkendall, X Xkyra, X Xmegan, X Xmph, X Xms, X Xthomas, X Xtoby, X
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on asthmatic children in the community, particularly in the high-risk urban environment, is less well-defined. OBJECTIVE: We hypothesized that children with high-symptom upper respiratory viral infections have reduced airway function and greater respiratory tract inflammation than children with virus-positive low-symptom illnesses or virus-negative upper respiratory tract symptoms. METHODS: We studied 53 asthmatic children from Detroit, Michigan during scheduled surveillance periods and self-reported respiratory illnesses for one year. Symptom score, spirometry, fraction of exhaled nitric oxide (FeNO) and nasal aspirate biomarkers, viral nucleic acid and rhinovirus (RV) copy number were assessed. RESULTS: Of 658 aspirates collected, 22.9% of surveillance samples and 33.7% of respiratory illnesses were virus-positive. Compared to the virus-negative asymptomatic condition, children with severe colds (symptom score ≥5) showed reduced forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75), higher nasal mRNA expression of C-X-C motif chemokine ligand (CXCL)-10 and melanoma differentiation-associated protein 5, and higher protein abundance of CXCL8, CXCL10 and C-C motif chemokine ligands (CCL)-2, CCL4, CCL20 and CCL24. Children with mild (symptom score 1–4) and asymptomatic infections showed normal airway function and fewer biomarker elevations. Virus-negative cold-like illnesses demonstrated increased FeNO, minimal biomarker elevation and normal airflow. RV copy number was associated with nasal chemokine levels but not symptom score. CONCLUSION: Urban asthmatic children with high-symptom respiratory viral infections have reduced FEF25–75 and more elevations of nasal biomarkers than children with mild or asymptomatic infections, or virus-negative illnesses.
has issue date	2019-02-01(xsd:dateTime)
bibo:doi	10.1016/j.anai.2018.10.021
bibo:pmid	30385348
has license	green-oa
sha1sum (hex)	7671df838f978a12b1cf45e324085c22c3a98d0e
schema:url	https://doi.org/10.1016/j.anai.2018.10.021
resource representing a document's title	Impact of community respiratory viral infections in urban children with asthma
has PubMed Central identifier	PMC6360098
has PubMed identifier	30385348
schema:publication	Annals of Allergy, Asthma & Immunology
resource representing a document's body	covid:7671df838f978a12b1cf45e324085c22c3a98d0e#body_text
is schema:about of	named entity 'self-reported' named entity 'chemokine' named entity 'aspirates' named entity 'melanoma' named entity 'respiratory illnesses' named entity 'hypothesized' named entity 'mild' named entity 'respiratory' named entity 'nasal' named entity 'score' named entity 'aspirate' named entity 'urban environment' named entity 'Impact' named entity 'respiratory' named entity 'MILD' named entity 'FENO' named entity 'NASAL' named entity 'LOW' named entity 'CONDITION' named entity 'RESPIRATORY TRACT INFLAMMATION' named entity 'FRACTION OF EXHALED NITRIC OXIDE' named entity 'UPPER RESPIRATORY TRACT SYMPTOMS' named entity 'NATURAL' named entity 'COLD' named entity 'MICHIGAN' named entity 'GREATER' named entity 'INCREASED' named entity 'MESSENGER RNA' named entity 'ASTHMA' named entity 'CCL4' named entity 'ELEVATION' named entity 'MINIMAL' named entity 'PERIODS' named entity 'METHODS' named entity 'COLLECTED' named entity 'NEGATIVE' named entity 'ASYMPTOMATIC INFECTIONS' named entity 'IMPACT' named entity 'SCHEDULED' named entity 'SURVEILLANCE' named entity 'AIRWAY' named entity 'CXCL8' named entity 'PROTEIN ABUNDANCE' named entity 'RESPIRATORY' named entity 'HIGH' named entity 'CHEMOKINE' named entity 'BIOMARKER' named entity 'COMMUNITY' named entity 'URBAN' named entity 'VIRAL INFECTIONS' named entity 'IMPACT'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software