About: Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs

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About: Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs
Creator	Vlasova, Anastasia Rajashekara, Gireesh Kumar, Anand Saif, Linda Chepngeno, Juliet Fischer, David Deblais, Loic Huang, Huang-Chi Kandasamy, Sukumar Shao, Lulu Alhamo, Moyasar An, Vlasova Candelero-Rueda, Rosario Dd, Fischer Fc, Paim Huang, Shao Langel, Stephanie Ma, Alhamo Mcdonald, Marie Paim, Francine Sarah, Editor Sn, Langel Tech, Virginia
Source	PMC
abstract	Malnutrition affects millions of children in developing countries, compromising immunity and contributing to increased rates of death from infectious diseases. Rotavirus is a major etiological agent of childhood diarrhea in developing countries, where malnutrition is prevalent. However, the interactions between the two and their combined effects on immune and intestinal functions are poorly understood. In this study, we used neonatal gnotobiotic (Gn) pigs transplanted with the fecal microbiota of a healthy 2-month-old infant (HIFM) and fed protein-deficient or -sufficient bovine milk diets. Protein deficiency induced hypoproteinemia, hypoalbuminemia, hypoglycemia, stunting, and generalized edema in Gn pigs, as observed in protein-malnourished children. Irrespective of the diet, human rotavirus (HRV) infection early, at HIFM posttransplantation day 3 (PTD3), resulted in adverse health effects and higher mortality rates (45 to 75%) than later HRV infection (PTD10). Protein malnutrition exacerbated HRV infection and affected the morphology and function of the small intestinal epithelial barrier. In pigs infected with HRV at PTD10, there was a uniform decrease in the function and/or frequencies of natural killer cells, plasmacytoid dendritic cells, and CD103(+) and apoptotic mononuclear cells and altered gene expression profiles of intestinal epithelial cells (chromogranin A, mucin 2, proliferating cell nuclear antigen, SRY-Box 9, and villin). Thus, we have established the first HIFM-transplanted neonatal pig model that recapitulates major aspects of protein malnutrition in children and can be used to evaluate physiologically relevant interventions. Our findings provide an explanation of why nutrient-rich diets alone may lack efficacy in malnourished children. IMPORTANCE Malnutrition and rotavirus infection, prevalent in developing countries, individually and in combination, affect the health of millions of children, compromising their immunity and increasing the rates of death from infectious diseases. However, the interactions between the two and their combined effects on immune and intestinal functions are poorly understood. We have established the first human infant microbiota-transplanted neonatal pig model of childhood malnutrition that reproduced the impaired immune, intestinal, and other physiological functions seen in malnourished children. This model can be used to evaluate relevant dietary and other health-promoting interventions. Our findings provide an explanation of why adequate nutrition alone may lack efficacy in malnourished children.
has issue date	2017-03-01(xsd:dateTime)
bibo:doi	10.1128/msphere.00046-17
bibo:pmid	28261667
has license	cc-by
sha1sum (hex)	765e023ee18436394fa56d1b2a388422e6201804
schema:url	https://doi.org/10.1128/msphere.00046-17
resource representing a document's title	Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs
has PubMed Central identifier	PMC5332602
has PubMed identifier	28261667
schema:publication	mSphere
resource representing a document's body	covid:765e023ee18436394fa56d1b2a388422e6201804#body_text
is schema:about of	named entity 'NEONATAL' named entity 'Malnutrition' named entity 'neonatal' named entity 'adverse' named entity 'compromising' named entity 'physiologically' named entity 'infection' named entity 'malnourished' named entity 'The levels' named entity 'provide' named entity 'pig' named entity 'Issue' named entity 'intestinal epithelial cells' named entity 'diarrhea' named entity 'cytokine' named entity 'immune' named entity 'natural killer cells' named entity 'rotavirus' named entity 'diets' named entity 'INNATE IMMUNITY' named entity 'EPITHELIAL CELLS' named entity 'ALPHA INTERFERON' named entity 'DIET' named entity 'MONTH' named entity 'COMBINED' named entity 'INTERACTIONS' named entity 'LACK' named entity 'SRY-BOX 9' named entity 'IMPAIRED' named entity 'UNDERSTOOD' named entity 'WHERE' named entity 'IL-10' named entity 'RATES' named entity 'CYTOKINES' named entity 'FED' named entity 'EVALUATE' named entity 'HIGHER' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'FECAL' named entity 'HEALTHY' named entity 'NATURAL KILLER CELLS' named entity 'BARRIER' named entity 'PREVALENT' named entity 'MAJOR' named entity 'HAVE' named entity 'DIETARY' named entity 'ASM' named entity 'INDUCED' named entity 'DEVELOPING COUNTRIES' named entity 'FREQUENCIES' named entity 'CONTRIBUTING' named entity 'RICH' named entity 'AFFECT' named entity 'MALNUTRITION IN CHILDREN' named entity 'MONONUCLEAR CELLS' named entity 'EPITHELIAL' named entity 'A MAJOR' named entity 'EXAMINED' named entity 'PREVIOUSLY'

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