About: Long-term follow-up of autologous hematopoietic stem cell transplantation for refractory juvenile dermatomyositis: a case-series study

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About: Long-term follow-up of autologous hematopoietic stem cell transplantation for refractory juvenile dermatomyositis: a case-series study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long-term follow-up of autologous hematopoietic stem cell transplantation for refractory juvenile dermatomyositis: a case-series study
Creator	Kang, Min Zhu, Jia Dong, Boya Lai, Jianming Li, Shengnan Su, Gaixiu Wu, Fengqi Zhou, Zhixuan
Source	PMC
abstract	OBJECTIVE: To follow up the refractory juvenile dermatomyositis (JDM) with autologous hematopoietic stem cell transplantation (AHSCT) in a long time and to investigate whether AHSCT is effective and safe to treat refractory JDM. METHODS: We collected the AHSCT and follow-up data of three patients with refractory JDM who received autologous peripheral blood CD34+ cell transplantation in our hospital between June 2004 and July 2015. Those data include: hight, weight, routine blood and urine tests, ESR, CK, ALT, AST, LDH, renal functional tests, lymphocyte subpopulations, HRCT and muscle MRI. The last follow-up was done in June 2017. RESULTS: All three patients had complete remission and could stop prednisone after 3–12 months. None of them relapsed at 144, 113 and 23 months follow-up. Twelve months after their AHSCT, all of their monitoring indexes have returned to normal and they have stopped all medications. Until the date of this article, none of them relapsed or need medicine. CONCLUSION: Our study suggests that AHSCT is safe and effective in treating refractory JDM, and it can provides long term drug-free survival. However, more cases are needed for further confirmation.
has issue date	2018-11-20(xsd:dateTime)
bibo:doi	10.1186/s12969-018-0284-3
bibo:pmid	30458860
has license	cc-by
sha1sum (hex)	76584b14f37aecde3e2c357ad302bca0aea9842c
schema:url	https://doi.org/10.1186/s12969-018-0284-3
resource representing a document's title	Long-term follow-up of autologous hematopoietic stem cell transplantation for refractory juvenile dermatomyositis: a case-series study
has PubMed Central identifier	PMC6245778
has PubMed identifier	30458860
schema:publication	Pediatr Rheumatol Online J
resource representing a document's body	covid:76584b14f37aecde3e2c357ad302bca0aea9842c#body_text
is schema:about of	named entity 'investigate' named entity 'autologous hematopoietic stem cell transplantation' named entity 'case' named entity 'AHSCT' named entity 'JDM' named entity 'juvenile dermatomyositis' named entity 'autologous hematopoietic stem cell transplantation' named entity 'follow-up' named entity 'HRCT' named entity 'adverse effects' named entity 'WBC' named entity 'ATG' named entity 'CD4' named entity 'distal' named entity 'alemtuzumab' named entity 'aetiology' named entity 'peripheral blood' named entity 'distal' named entity 'ganciclovir' named entity 'cytokines' named entity 'JDM' named entity 'JDM' named entity 'muscle weakness' named entity 'Autologous hematopoietic stem cell transplantation' named entity 'proximal' named entity 'JDM' named entity 'follow-up' named entity 'rash' named entity 'prednisone' named entity 'CD4+' named entity 'G-CSF' named entity 'muscle biopsy' named entity 'magnetic resonance imaging' named entity 'G-CSF' named entity 'dysphonia' named entity 'inflammatory disorder' named entity 'lung' named entity 'corticosteroids' named entity 'JDM' named entity 'serum' named entity 'Antibiotics' named entity 'ANA' named entity 'rash' named entity 'pathogenesis' named entity 'peripheral blood' named entity 'methotrexate' named entity 'JDM' named entity 'urine tests' named entity 'long-term' named entity 'lymphocyte' named entity 'refractory' named entity 'rash' named entity 'EMG' named entity 'rash' named entity 'SSc' named entity 'autoimmune diseases' named entity 'JDM' named entity 'Blood and Marrow Transplantation' named entity 'prognosis' named entity 'Rheumatology' named entity 'refractory' named entity 'environmental triggers' named entity 'China' named entity 'JDM' named entity 'refractory' named entity 'Juvenile dermatomyositis' named entity 'autoimmune' named entity 'ESR' named entity 'refractory' named entity 'Rheumatology' named entity 'follow-up' named entity 'refractory' named entity 'AHSCT' named entity 'HGB'

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