About: Evaluation of rapid antigen test for detection of SARS-CoV-2 virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of rapid antigen test for detection of SARS-CoV-2 virus
Creator	Chan, Dominic Cheng, Peter Lau, C Mak, C Wong, Kitty Rickjason, C Lam, T Gannon, * Nc, Tsang Sy Lau, Stephen
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The rapid diagnosis of COVID-19 patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests. OBJECTIVE: To evaluate the performance of BIOCREDIT COVID-19 Ag test and compared it with real-time RT-PCR for detecting SARS-CoV-2 virus. Study Design: Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture and PCR as a reference methods. The RAD test was further evaluated using respiratory samples collected from confirmed COVID-19 patients. The results were compared with RT-PCR test. RESULTS: The detection limits between RAD test, viral culture and PCR varied hugely. RAD was 103 fold less sensitive than viral culture while RAD was 105 fold less sensitive than RT-PCR. The RAD test detected between 11.1% and 45.7% of real-time RT-PCR-positive samples from COVID-19 patients. CONCLUSIONS: This study demonstrated that the RAD test serve only as adjunct to RT-PCR test because of potential for false-negative results.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2020.104500
bibo:pmid	32585619
has license	no-cc
sha1sum (hex)	75dbc1de68f6e09a13a21429541554dfee937c67
schema:url	https://doi.org/10.1016/j.jcv.2020.104500
resource representing a document's title	Evaluation of rapid antigen test for detection of SARS-CoV-2 virus
has PubMed Central identifier	PMC7278630
has PubMed identifier	32585619
schema:publication	J Clin Virol
resource representing a document's body	covid:75dbc1de68f6e09a13a21429541554dfee937c67#body_text
is schema:about of	named entity 'samples' named entity 'antigen' named entity 'Supervision' named entity 'Methodology' named entity 'Lam' named entity 'Validation' named entity 'N A' named entity 'VIRAL CULTURE' named entity 'SAMPLES' named entity 'PCR' named entity 'essential' named entity 'PCR' named entity 'COVID-19' named entity 'disease' named entity 'sensitive' named entity 'essential' named entity 'disease' named entity 'diagnosis' named entity 'Chan' named entity 'antigen detection' named entity 'false-negative' named entity 'COVID' named entity 'SARS-CoV-2 virus' named entity 'diluent' named entity 'infection' named entity 'antigen detection' named entity 'LOD' named entity 'diluent' named entity 'turnaround time' named entity 'antigen detection' named entity 'diluent' named entity 'Severe Acute Respiratory Syndrome Coronavirus 2' named entity 'Hong Kong' named entity 'VTM' named entity 'Coronavirus disease 2019' named entity 'World Health Organization' named entity 'viral load' named entity 'virus' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'genus' named entity 'viral culture' named entity 'diluent' named entity 'virus' named entity 'WHO' named entity 'antibody' named entity 'SARS-CoV-2' named entity 'nucleic acid' named entity 'Hong Kong' named entity 'SARS-CoV-2' named entity 'viscous' named entity 'antigen' named entity 'antigen' named entity 'nasopharyngeal swab' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2 virus' named entity 'Hong Kong' named entity 'COVID' named entity 'infection' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'LOD' named entity 'real-time RT-PCR' named entity 'eluted' named entity 'COVID' named entity 'RT-PCR' named entity 'viscous' named entity 'viral culture' named entity 'saliva' named entity 'SARS-CoV-2 virus' named entity 'gold standards' named entity 'sputum'

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