About: SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal

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About: SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface
Creator	Chen, Wei Yang, Ming Chen, W Yuan, Peng Chen, Y Liu, X Yan, L Yan, Z Yang, M Qiao, Jie Yan, Jie Chen, Yidong Kong, Siming Kong, S Liu, Xixi Yan, J Yan, Liying Yan, Zhiqiang Yuan, P Qiao, J
source	Elsevier; Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world, leading to large-scale population infection. Angiotensin-converting enzyme 2 (ACE2) is the receptor of both severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. However, it is still controversial whether vertical transmission exists. In order to investigate the potential risk of SARS-CoV-2 vertical transmission, we explored ACE2 and transmembrane protease serine 2 (TMPRSS2) expression patterns in peri-implantation embryos and the maternal–fetal interface using previously published single-cell transcriptome data. The results show that day 6 (D6) trophectoderm cells (TE) in peri-implantation embryos, as well as syncytiotrophoblast (STB) at 8 weeks of gestation (STB_8W) and extravillous trophoblasts cells (EVT) at 24 weeks of gestation (EVT_24W) in the maternal–fetal interface, strongly co-expressed ACE2 and TMPRSS2, indicating SARS-CoV-2 infection susceptibility. The ACE2 positive-expressing cells in the three cell types mentioned above are found to share common characteristics, which are involved in autophagy and immune-related processes. ACE2 showed no gender bias in post-implantation embryos but showed a significant gender difference in D6_TE, D6 primitive endoderm cells (PE), and ACE2 positive-expressing STBs. These findings indicate that there may be different SARS-CoV-2 infection susceptibilities of D6 embryos of different genders and during the gestation of different genders. Our results reveal potential SARS-CoV-2 infection risks during embryo transfer, peri-implantation embryo development, and gestation.
has issue date	2020-08-17(xsd:dateTime)
bibo:doi	10.1016/j.eng.2020.07.013
bibo:pmid	32837754
has license	no-cc
sha1sum (hex)	75880d07f092232199a067d8212568419537c569
schema:url	https://doi.org/10.1016/j.eng.2020.07.013
resource representing a document's title	SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface
has PubMed Central identifier	PMC7429517
has PubMed identifier	32837754
schema:publication	Engineering (Beijing)
resource representing a document's body	covid:75880d07f092232199a067d8212568419537c569#body_text
is schema:about of	named entity 'day 6' named entity 'These' named entity 'gender bias' named entity 'patterns' named entity 'population' named entity 'Peri' named entity 'ARTICLE' named entity 'Embryos' named entity 'TMPRSS2' named entity 'VERTICAL TRANSMISSION' named entity 'SUSCEPTIBILITY' named entity 'INTERFACE' named entity 'EMBRYO DEVELOPMENT' named entity 'INDICATING' named entity 'transcriptome' named entity 'Our' named entity 'embryos' named entity 'protease' named entity 'genders' named entity 'gestation' named entity 'severe acute respiratory syndrome coronavirus' named entity 'leading' named entity 'cells' named entity 'serine' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'single-cell' named entity 'autophagy' named entity 'transcriptome' named entity 'ACE2' named entity 'transmembrane' named entity 'expression patterns' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'embryos' named entity 'vertical transmission' named entity 'SARS-CoV' named entity 'ACE2' named entity 'ACE2' named entity 'Embryos' named entity 'SARS-CoV-2' named entity 'neonates' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'embryo' named entity 'stromal cells' named entity 'ACE2' named entity 'chromosome' named entity 'SARS-CoV-2' named entity 'endothelium' named entity 'gender bias' named entity 'immunofluorescence' named entity 'RefSeq' named entity 'virus' named entity 'infection' named entity 'pregnancy' named entity 'infection' named entity 'blood vessel wall' named entity 'transcriptome' named entity 'cell-type'

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