About: Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine

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About: Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine
Creator	Ewer, Katie Gilbert, Sarah Bowyer, Georgina Bellamy, Duncan Berrie, Eleanor Edwards, Nick Folegatti, Pedro Green, Nicky Hermon-Taylor, John Hill, Adrian Lawrie, Alison Mair, Catherine Mitton, Celia Poulton, Ian Powlson, Jonathan Roberts, Rachel
Source	PMC
abstract	Adenovirus vectored vaccines are a highly effective strategy to induce cellular immune responses which are particularly effective against intracellular pathogens. Recombinant simian adenovirus vectors were developed to circumvent the limitations imposed by the use of human adenoviruses due to widespread seroprevalence of neutralising antibodies. We have constructed a replication deficient simian adenovirus-vectored vaccine (ChAdOx2) expressing 4 genes from the Mycobacterium avium subspecies paratuberculosis (AhpC, Gsd, p12 and mpa). Safety and T-cell immunogenicity results of the first clinical use of the ChAdOx2 vector are presented here. The trial was conducted using a ‘three-plus-three’ dose escalation study design. We demonstrate the vaccine is safe, well tolerated and immunogenic.
has issue date	2019-05-15(xsd:dateTime)
bibo:doi	10.3390/vaccines7020040
bibo:pmid	31096710
has license	cc-by
sha1sum (hex)	7531c4305658b8cf4fa576ae050d7162043fe535
schema:url	https://doi.org/10.3390/vaccines7020040
resource representing a document's title	Safety and Immunogenicity of a Novel Recombinant Simian Adenovirus ChAdOx2 as a Vectored Vaccine
has PubMed Central identifier	PMC6630572
has PubMed identifier	31096710
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:7531c4305658b8cf4fa576ae050d7162043fe535#body_text
is schema:about of	named entity 'MPA' named entity 'IMMUNOGENICITY' named entity 'ADENOVIRUS' named entity 'CLINICAL' named entity 'RESULTS' named entity 'SAFETY' named entity 'EFFECTIVE' named entity 'TRIAL' named entity 'HIGHLY' named entity 'USING' named entity 'CELLULAR' named entity 'WIDESPREAD' named entity 'trial' named entity 'intracellular pathogens.' named entity 'expressing' named entity 'Simian' named entity 'VACCINE' named entity 'HUMAN' named entity 'VECTORED' named entity 'VECTOR' named entity 'REPLICATION' named entity 'CONSTRUCTED' named entity 'STRATEGY' named entity 'MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS' named entity 'SAFE' named entity 'ADENOVIRUSES' named entity 'USE OF' named entity 'DOSE ESCALATION' named entity 'P12' named entity 'SEROPREVALENCE' covid:arg/7531c4305658b8cf4fa576ae050d7162043fe535 named entity 'NOVEL' named entity 'VECTORED' named entity 'RECOMBINANT' named entity 'SAFETY' named entity 'IMMUNOGENIC' named entity 'RECOMBINANT' named entity 'T-CELL' named entity 'GENES' named entity 'SIMIAN ADENOVIRUS' named entity 'INDUCE' named entity 'INTRACELLULAR PATHOGENS' named entity 'NEUTRALISING ANTIBODIES' named entity 'DEFICIENT' named entity 'VACCINE' named entity 'LIMITATIONS' named entity 'IMMUNOGENICITY' named entity 'SIMIAN ADENOVIRUS' named entity 'VECTORS' named entity 'HAVE' named entity 'HERE' named entity 'VACCINES' named entity 'GSD' named entity 'STUDY DESIGN' named entity 'IMMUNE RESPONSES' named entity 'DUE TO' named entity 'PRESENTED' named entity 'escalation' named entity 'cellular immune responses' named entity 'vectors' named entity 'subspecies' named entity 'adenovirus' named entity 'Adenovirus' named entity 'adenovirus' named entity 'vector' named entity 'adenoviruses'

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