About: A longitudinal study of immune cells in severe COVID-19 patients.

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A longitudinal study of immune cells in severe COVID-19 patients. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A longitudinal study of immune cells in severe COVID-19 patients.
Creator	Dupuis, Claire Payen, Didier Chru-Nancy, Bittencourt Cravat, Maxime De Carvalho Bittencourt, Marcelo De Carvalho, Marcelo Didelot, Carole Losser, Marie-Reine Maadadi, Hadil Prosic, Lydia
Source	MedRxiv
abstract	Little is known about the time-dependent immune responses in severe COVID-19. Data of 15 consecutive patients were sequentially recorded from intensive care unit admission. Lymphocyte subsets and total monocyte and subsets counts were monitored as well as the expression of HLA-DR. For 5 patients, SARS-CoV-2-specific T-cell polyfunctionality was assessed against Spike and Nucleoprotein SARS-CoV-2 peptides. Non-specific inflammation markers were increased in all patients. Median monocyte HLA-DR expression was below the 8,000 AB/C threshold defining acquired immunodepression. A V trend curve for lymphopenia, monocyte numbers, and HLA-DR expression was observed with a nadir between days 11-14 after the onset of symptoms. Intermediate CD14++CD16+ monocytes increased early with a reduction in classic CD14++CD16- monocytes. Polyfunctional SARS-Cov-2-specific CD4 T-cells were present and functional, whereas virus-specific CD8 T-cells were less frequent and not efficient. We report a temporal variation of both innate and adaptive immunity in severe COVID-19 patients, helpful in guiding therapeutic decisions (e.g. anti-inflammatory vs. immunostimulatory ones). We describe a defect in virus-specific CD8 T-cells, a potential biomarker of clinical severity. These combined data also provide helpful knowledge for vaccine design.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1101/2020.06.16.20130914
has license	medrxiv
sha1sum (hex)	752ef63234307a3ee83a565cedd1752c7fe0d5f5
schema:url	https://doi.org/10.1101/2020.06.16.20130914
resource representing a document's title	A longitudinal study of immune cells in severe COVID-19 patients.
resource representing a document's body	covid:752ef63234307a3ee83a565cedd1752c7fe0d5f5#body_text
is schema:about of	covid:arg/752ef63234307a3ee83a565cedd1752c7fe0d5f5 named entity 'Spike' named entity 'total' named entity 'Median' named entity 'subsets' named entity 'monitored' named entity 'patients' named entity 'observed' named entity 'onset' named entity 'HLA-DR' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'intensive care unit' named entity 'CC-BY-NC-ND 4.0' named entity 'lymphocytes' named entity 'T-cells' named entity 'PBMC' named entity 'CD4 +' named entity 'ICU' named entity 'monocytes' named entity 'TH1' named entity 'T-cells' named entity 'Berlin' named entity 'T-cells' named entity 'cytometer' named entity 'SARS-CoV-2' named entity 'antigens' named entity 'ICU' named entity 'peptide' named entity 'CD16' named entity 'CD8 T-cells' named entity 'CD4' named entity 'leukocyte' named entity 'CD8 +' named entity 'IL-2' named entity 'diabetes' named entity 'medRxiv' named entity 'monocytes' named entity 'B-cells' named entity 'CC-BY-NC-ND 4.0' named entity 'inflammatory response' named entity 'antibody' named entity 'CD4' named entity 'medRxiv' named entity 'immunophenotyping' named entity 'monocyte' named entity 'Lymphocyte' named entity 'vaccine' named entity 'June 19' named entity 'PBMC' named entity 'medRxiv' named entity 'T-cells' named entity 'infection' named entity 'ICU' named entity 'positive controls' named entity 'medRxiv' named entity 'CD8 T-cells' named entity 'San Jose' named entity 'CD8' named entity 'peptide' named entity 'Nucleoprotein' named entity 'Monos' named entity 'monocyte' named entity 'medRxiv' named entity 'CD4' named entity 'ICU' named entity 'monocyte' named entity 'lymphopenia' named entity 'microbial' named entity 'lymphocytes' named entity 'Berlin' named entity 'anti-viral' named entity 'CD4 T-cells' named entity 'IFN-γ' named entity 'HLA-DR' named entity 'phenotypic'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software