About: RNA structure analysis of alphacoronavirus terminal genome regions

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RNA structure analysis of alphacoronavirus terminal genome regions
Creator	Ziebuhr, John Madhugiri, Ramakanth Marz, Manja Fricke, Markus
topic	covid:751ffc336c6d7846e4d9018ad8ad6234e06056ed#this
Source	Elsevier; Medline; PMC
abstract	Abstract Coronavirus genome replication is mediated by a multi-subunit protein complex that is comprised of more than a dozen virally encoded and several cellular proteins. Interactions of the viral replicase complex with cis-acting RNA elements located in the 5′ and 3′-terminal genome regions ensure the specific replication of viral RNA. Over the past years, boundaries and structures of cis-acting RNA elements required for coronavirus genome replication have been extensively characterized in betacoronaviruses and, to a lesser extent, other coronavirus genera. Here, we review our current understanding of coronavirus cis-acting elements located in the terminal genome regions and use a combination of bioinformatic and RNA structure probing studies to identify and characterize putative cis-acting RNA elements in alphacoronaviruses. The study suggests significant RNA structure conservation among members of the genus Alphacoronavirus but also across genus boundaries. Overall, the conservation pattern identified for 5′ and 3′-terminal RNA structural elements in the genomes of alpha- and betacoronaviruses is in agreement with the widely used replicase polyprotein-based classification of the Coronavirinae, suggesting co-evolution of the coronavirus replication machinery with cognate cis-acting RNA elements.
has issue date	2014-12-19(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.10.001
bibo:pmid	25307890
has license	els-covid
sha1sum (hex)	751ffc336c6d7846e4d9018ad8ad6234e06056ed
schema:url	https://doi.org/10.1016/j.virusres.2014.10.001
resource representing a document's title	RNA structure analysis of alphacoronavirus terminal genome regions
has PubMed Central identifier	PMC7114417
has PubMed identifier	25307890
schema:publication	Virus Research
resource representing a document's body	covid:751ffc336c6d7846e4d9018ad8ad6234e06056ed#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/751ffc336c6d7846e4d9018ad8ad6234e06056ed
is schema:about of	named entity 'REGIONS' named entity 'STRUCTURE ANALYSIS' named entity 'CELLULAR' named entity 'CURRENT' named entity 'POLYPROTEIN' named entity 'INTERACTIONS' named entity 'REQUIRED' named entity 'PROTEIN COMPLEX' named entity 'TERMINAL' named entity 'SIGNIFICANT' named entity 'CORONAVIRINAE' named entity 'PROTEINS' named entity 'OUR' named entity 'RNA STRUCTURE' named entity 'CONSERVATION' named entity 'OVERALL' named entity 'AGREEMENT' named entity 'GENUS' named entity 'VIRAL' named entity 'VIRAL RNA' named entity 'CORONAVIRUS' named entity 'RNA STRUCTURE' named entity 'TERMINAL' named entity 'GENOME' named entity 'ALPHACORONAVIRUS' named entity 'LOCATED IN' named entity 'MEDIATED' named entity 'EXTENT' named entity 'YEARS' named entity 'REPLICASE' named entity 'TO IDENTIFY' named entity 'BUT' named entity 'RNA' named entity 'SUBUNIT' named entity 'ACROSS' named entity 'HAVE' named entity 'CIS' named entity 'MACHINERY' named entity 'PAST' named entity 'CO-EVOLUTION' named entity 'USED' named entity 'GENOMES' named entity 'GENOME' named entity 'BIOINFORMATIC' named entity 'CHARACTERIZED' named entity 'COMBINATION' named entity 'IDENTIFIED' named entity 'STRUCTURAL' named entity 'UNDERSTANDING' named entity 'REPLICATION' named entity 'COMPLEX' named entity 'HERE' named entity 'MORE THAN' named entity 'PROBING' named entity 'ENSURE' named entity 'STRUCTURES' named entity 'REGIONS' named entity 'STUDIES' named entity 'BOUNDARIES' named entity 'STUDY' named entity 'BASED' named entity 'BETACORONAVIRUSES' named entity 'MULTI' named entity 'ALPHA' named entity 'ELEMENTS' named entity 'PATTERN' named entity 'LESSER' named entity 'SPECIFIC' named entity 'ENCODED' named entity 'MEMBERS' named entity 'USE' named entity 'GENUS ALPHACORONAVIRUS' named entity 'CLASSIFICATION' named entity 'REVIEW' covid:arg/751ffc336c6d7846e4d9018ad8ad6234e06056ed named entity 'betacoronaviruses'

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