About: Oropharyngeal candidiasis in hospitalized COVID‐19 Patients from Iran: Species identification and antifungal susceptibility pattern

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About: Oropharyngeal candidiasis in hospitalized COVID‐19 Patients from Iran: Species identification and antifungal susceptibility pattern Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oropharyngeal candidiasis in hospitalized COVID‐19 Patients from Iran: Species identification and antifungal susceptibility pattern
Creator	Ebrahimi, Saeedeh Ghiasvand, Fereshteh Salehi, Mohammadreza Seifi, Arash Kalantari, Saeed Boekhout, Teun Ahmadikia, Kazem Khodavaisy, Sadegh Dehghan Manshadi, Seyed Izadi, Alireza Khajavirad, Nasim Koohfar, Amirhossein Kord, Mohammad Mahmoudi, Shahram Siahkali, Saeidreza
Source	Medline; PMC
abstract	BACKGROUND: Emergence of coronavirus disease 2019 (COVID‐19) is a major healthcare threat. Apparently, the novel coronavirus (SARS‐CoV‐2) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal candidiasis (OPC) development in COVID‐19 patients with a list of attributable risk factors for oral infections has not yet been investigated. OBJECTIVES: We here aim to investigate the prevalence, causative agents, and antifungal susceptibility pattern of OPC in Iranian COVID‐19 patients. PATIENTS AND METHODS: A total of 53 hospitalized COVID‐19 patients with OPC were studied. Relevant clinical data were mined. Strain identification was performed by 21‐plex PCR and sequencing of the internal transcribed spacer region (ITS1‐5.8S‐ITS2). Antifungal susceptibility testing to fluconazole, itraconazole, voriconazole, amphotericin B, caspofungin, micafungin and anidulafungin was performed according to the CLSI broth dilution method. RESULTS: In 53 COVID‐19 patients with OPC, cardiovascular diseases (52.83 %), and diabetes (37.7 %) were the principal underlying conditions. The most common risk factor was lymphopenia (71%). In total, 65 Candida isolates causing OPC were recovered. C. albicans (70.7%) was the most common, followed by C. glabrata (10.7%), C. dubliniensis (9.2%), C. parapsilosis sensu stricto (4.6%), C. tropicalis (3%), and Pichia kudriavzevii (=C. krusei, 1.5%). Majority of the Candida isolates were susceptible to all three classes of antifungal drugs. CONCLUSION: Our data clarified some concerns regarding the occurrence of OPC in Iranian COVID‐19 patients. Further studies should be conducted to design an appropriate prophylaxis program and improve management of OPC in critically ill COVID‐19 patients.
has issue date	2020-07-01(xsd:dateTime)
bibo:doi	10.1111/myc.13137
bibo:pmid	32609906
has license	no-cc
sha1sum (hex)	751f195a759e74a7987bb7e243b04f1a5d9ef264
schema:url	https://doi.org/10.1111/myc.13137
resource representing a document's title	Oropharyngeal candidiasis in hospitalized COVID‐19 Patients from Iran: Species identification and antifungal susceptibility pattern
has PubMed Central identifier	PMC7361944
has PubMed identifier	32609906
schema:publication	Mycoses
resource representing a document's body	covid:751f195a759e74a7987bb7e243b04f1a5d9ef264#body_text
is schema:about of	named entity 'SARS-CoV-2' covid:arg/751f195a759e74a7987bb7e243b04f1a5d9ef264 named entity 'attributable risk' named entity 'oral' named entity 'patients' named entity 'mortality rate' named entity 'oropharynx' named entity 'KOH' named entity '5.8S rDNA' named entity 'antifungal agents' named entity 'risk factors' named entity 'esophagus' named entity 'upper gastrointestinal tract' named entity 'COVID' named entity 'yeast infection' named entity 'morbidity' named entity 'immune mechanism' named entity 'Broad spectrum antibiotics' named entity 'SARS-CoV' named entity 'yeast' named entity 'Candida' named entity 'virus' named entity 'Candida' named entity 'candidiasis' named entity 'lymphocytes' named entity 'yeasts' named entity 'oral mucosa' named entity 'Wuhan' named entity 'fungal infections' named entity 'oral cavity' named entity 'COVID' named entity 'COVID' named entity 'Hubei Province' named entity 'oropharyngeal candidiasis' named entity 'risk factors' named entity 'corticosteroid' named entity 'lymphocytes' named entity 'mucocutaneous' named entity 'fluconazole' named entity 'Chi-Square test' named entity 'lymphocyte' named entity 'lymphocytes' named entity 'acute respiratory distress syndrome' named entity 'COVID' named entity 'viral pathogen' named entity 'Pichia' named entity 'tertiary care' named entity 'C. dubliniensis' named entity 'morbidity' named entity 'antifungal drugs' named entity 'SARS-CoV-2' named entity 'infection' named entity 'Detroit' named entity 'morbidity' named entity 'dysphagia' named entity 'C. parapsilosis' named entity 'seafood' named entity 'COVID-19' named entity 'Candida' named entity 'glossodynia' named entity 'C. dubliniensis' named entity 'mucosal' named entity 'pharmacological treatment' named entity 'immunocompromised' named entity 'COVID' named entity 'azoles' named entity 'immunocompromised'

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