About: Hematopoietic cellular aging is not accelerated during the first 2 years of life in children born preterm

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About: Hematopoietic cellular aging is not accelerated during the first 2 years of life in children born preterm Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hematopoietic cellular aging is not accelerated during the first 2 years of life in children born preterm
Creator	Degerman, Sofie Bohlin, Kajsa Haider, Zahra Henckel, Ewa Hultdin, Magnus Kosma, Paraskevi Landfors, Mattias
Source	Medline; PMC
abstract	BACKGROUND: Prematurity in itself and exposure to neonatal intensive care triggers inflammatory processes and oxidative stress, leading to risk for disease later in life. The effects on cellular aging processes are incompletely understood. METHODS: Relative telomere length (RTL) was measured by qPCR in this longitudinal cohort study with blood samples taken at birth and at 2 years of age from 60 children (16 preterm and 44 term). Viral respiratory infections the first year were evaluated. Epigenetic biological DNA methylation (DNAm) age was predicted based on methylation array data in 23 children (11 preterm and 12 term). RTL change/year and DNAm age change/year was compared in preterm and term during the 2 first years of life. RESULTS: Preterm infants had longer telomeres than term born at birth and at 2 years of age, but no difference in telomere attrition rate could be detected. Predicted epigenetic DNAm age was younger in preterm infants, but rate of DNAm aging was similar in both groups. CONCLUSIONS: Despite early exposure to risk factors for accelerated cellular aging, children born preterm exhibited preserved telomeres. Stress during the neonatal intensive care period did not reflect accelerated epigenetic DNAm aging. Early-life aging was not explained by preterm birth. IMPACT: Preterm birth is associated with elevated disease risk later in life. Preterm children often suffer from inflammation early in life. Stress-related telomere erosion during neonatal intensive care has been proposed. Inflammation-accelerated biological aging in preterm is unknown. We find no accelerated aging due to prematurity or infections during the first 2 years of life.
has issue date	2020-03-13(xsd:dateTime)
bibo:doi	10.1038/s41390-020-0833-6
bibo:pmid	32170191
has license	no-cc
sha1sum (hex)	7505f3e3ff9dabd65276932b8694bb374d33d8c8
schema:url	https://doi.org/10.1038/s41390-020-0833-6
resource representing a document's title	Hematopoietic cellular aging is not accelerated during the first 2 years of life in children born preterm
has PubMed Central identifier	PMC7086539
has PubMed identifier	32170191
schema:publication	Pediatr Res
resource representing a document's body	covid:7505f3e3ff9dabd65276932b8694bb374d33d8c8#body_text
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