About: Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective
Creator	Ganesh, Balasubramanian Goyal, Kapil Dhama, Kuldeep Tiwari, Ruchi Bhat, Sudipta Sircar, Shubhankar Kumar, Naveen Sah, Ranjit Kumar, Prashant Gupta, Parakriti Chikitsa, Pashu El Zowalaty, Mohamed Go, Evum Rodriguez-Morales, Alfonso Sansthan, Anusandhan Singh, Mini Singh, Raj Singh, Yashpal Upadhayay, Dayal Vishwavidyalay, Vigyan Ghoshal, Ujjala Patel, Shailesh Pathak, Mamta Yatoo, Iqbal Kaushik, Rahul
Source	Medline; PMC
abstract	The technology-driven world of the 21st century is currently confronted with a major threat to humankind, represented by the coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2). As of now, COVID-19 has affected more than 6 million confirmed cases and took 0.39 million human lives. SARS-CoV-2 spreads much faster than its two ancestors, SARS-CoV and Middle East respiratory syndrome-CoV (MERS-CoV), but has low fatality rates. Our analyses speculate that the efficient replication and transmission of SARS-CoV-2 might be due to the high-density basic amino acid residues, preferably positioned in close proximity at both the furin-like cleavage sites (S1/S2 and S2′) within the spike protein. Given the high genomic similarities of SARS-CoV-2 to bat SARS-like CoVs, it is likely that bats serve as a reservoir host for its progenitor. Women and children are less susceptible to SARS-CoV-2 infection, while the elderly and people with comorbidities are more prone to serious clinical outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. The cohesive approach amongst researchers across the globe has delivered high-end viral diagnostics. However, home-based point-of-care diagnostics are still under development, which may prove transformative in current COVID-19 pandemic containment. Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. In this review, we discuss the noteworthy advancements, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease epidemiology and diagnosis, animal reservoirs, laboratory animal models, disease transmission, therapeutics, vaccine challenges, and disease mitigation measures.
has issue date	2020-06-28(xsd:dateTime)
bibo:doi	10.3390/pathogens9070519
bibo:pmid	32605194
has license	cc-by
sha1sum (hex)	74b9adabe8ba46e0875c516c4ecd4852eb961cc8
schema:url	https://doi.org/10.3390/pathogens9070519
resource representing a document's title	Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective
has PubMed Central identifier	PMC7400054
has PubMed identifier	32605194
schema:publication	Pathogens
resource representing a document's body	covid:74b9adabe8ba46e0875c516c4ecd4852eb961cc8#body_text
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