About: 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization

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About: 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
Creator	De Martino, Luisa Fiorito, Filomena Iovane, Valentina Costagliola, Anna Giovanna, · Granato, Elvira Marullo, ·
source	Medline; PMC
abstract	Infection of kidney cells (MDBK) with Bovine Herpesvirus 1 (BoHV-1) is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which accelerates BoHV-1-induced apoptosis and increases virus replication. Herein, to elucidate the mechanism through TCDD modifies BoHV-1 infection, we analyzed the modulation of a members of Sirtuin proteins family in MDBK cells. We found that mitochondrial SIRT3 was upregulated during infection. This change was accompanied by cytoskeletal rearrangements and cell extensions. All these trends were drastically modified by TCDD. We hypothesize that, taken together, these results might further clarify the processes responsible for the action of TCDD on the BoHV-1 replication, resulting in enhanced virus production.
has issue date	2017-10-28(xsd:dateTime)
bibo:doi	10.1007/s11259-017-9701-1
bibo:pmid	29081026
has license	no-cc
sha1sum (hex)	74ab51a7173e4ee57a69fc6feb94efe064f29db5
schema:url	https://doi.org/10.1007/s11259-017-9701-1
resource representing a document's title	2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
has PubMed Central identifier	PMC7088714
has PubMed identifier	29081026
schema:publication	Vet Res Commun
resource representing a document's body	covid:74ab51a7173e4ee57a69fc6feb94efe064f29db5#body_text
is schema:about of	named entity 'REPLICATION' named entity 'SIRT3' named entity 'ABBREVIATIONS' named entity 'UPREGULATION' named entity 'P-DIOXIN' named entity 'BOVINE HERPESVIRUS 1' named entity 'CYTOSKELETAL REORGANIZATION' covid:arg/74ab51a7173e4ee57a69fc6feb94efe064f29db5 named entity 'replication' named entity 'Tetrachlorodibenzo-p-dioxin' named entity 'Immobilon' named entity 'infection' named entity 'infectious agents' named entity 'nitrocellulose' named entity 'TCDD' named entity 'TCDD' named entity 'actin' named entity 'actin' named entity 'cytoskeletal reorganization' named entity 'actin' named entity 'TCDD' named entity 'agarose' named entity 'PBS' named entity 'Concomitantly' named entity 'centrifugation' named entity 'SIRT3' named entity 'cell death' named entity 'β-actin' named entity 'down-regulation' named entity 'pg/mL' named entity 'Protein' named entity 'Bio-Rad' named entity 'Bio-Rad' named entity '0.01' named entity 'filopodia' named entity 'nucleus' named entity 'TCDD' named entity 'Densitometry' named entity 'Braunschweig' named entity 'electrophoresis' named entity 'fluorescence microscope' named entity 'toluene' named entity 'PBS' named entity 'TCDD' named entity 'bovine' named entity 'infection' named entity 'pathogen' named entity 'antibiotic' named entity 'staining' named entity 'infection' named entity 'San Diego' named entity 'actin cytoskeleton' named entity 'apoptosis' named entity 'morphological features' named entity 'Fluorescein Isothiocyanate' named entity 'culture media' named entity 'IBR' named entity 'actin filaments' named entity '0.01' named entity '37 °C' named entity 'organelles' named entity 'centrifugation' named entity 'virus' named entity 'SDS-PAGE' named entity 'statistically significant' named entity 'PBS' named entity 'SIRT3' named entity 'protein' named entity 'L-glutamine' named entity 'foetal calf serum' named entity 'sodium pyrophosphate' named entity 'pg/mL' named entity 'PBS' named entity 'loading control' named entity 'TCDD'

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