About: Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas

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About: Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas
Creator	Fukushima, Shoji Inoue, Masayo Kakehashi, Anna Wanibuchi, Hideki Wei, Min
Source	Elsevier; Medline; PMC
abstract	Abstract Screening of the proteome of microdissected glutathione S-transferase placental form (GST-P) positive foci and normal-appearing liver on anionic (Q10), and cationic (CM10) surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) ProteinChip arrays demonstrated significant overexpression of cytokeratin 8 (CK8; m/z 54,020), cytokeratin 18 (CK18; m/z 47,760), microsomal cytochrome 5A (m/z 15,224) and histone type 2 H2aa3 (m/z 15,964) in the livers of rats initiated with diethylnitrosamine (DEN) followed by 10 weeks on phenobarbital (PB) at a dose of 500 ppm. Furthermore, formation of CK8 and CK18 complexes due to CK8 phosphorylation at Ser73 and Ser431 was found to be strongly associated with promotion of hepatocarcinogenesis by PB and the development of hepatocellular carcinomas. The data were confirmed by immunohistochemistry and real-time Q-PCR and profound overexpression of CK8 and CK18 (CK8/18) proteins and mRNAs were detected in several large size GST-P positive foci and liver tumors. A strong correlation between CK8/18 positive foci development and multiplicity of hepatocellular carcinomas was further observed. Moreover, elevation of CK8/18 was strongly associated with induction of cell proliferation in GST-P positive foci and tumors. In conclusion, our data imply that CK8/18 overexpression, those two cytokeratins complex formation associated with histone type 2 H2aa3 up-regulation and intermediate filament reorganization may drive neoplastic transformation of GST-P positive foci during rat hepatocarcinogenesis leading to the formation of hepatocellular carcinomas.
has issue date	2009-07-01(xsd:dateTime)
bibo:doi	10.1016/j.taap.2009.04.018
bibo:pmid	19409407
has license	els-covid
sha1sum (hex)	7440e73586a86e38a773cb529bca7ffef7a1afb0
schema:url	https://doi.org/10.1016/j.taap.2009.04.018
resource representing a document's title	Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas
has PubMed Central identifier	PMC7126293
has PubMed identifier	19409407
schema:publication	Toxicology and Applied Pharmacology
resource representing a document's body	covid:7440e73586a86e38a773cb529bca7ffef7a1afb0#body_text
is schema:about of	named entity 'POSITIVE' named entity 'PLACENTAL' named entity 'INDICATOR' named entity 'LASER DESORPTION' named entity 'DEMONSTRATED' named entity 'SURFACE' named entity 'PHOSPHORYLATION' named entity 'UP-REGULATION' named entity 'TUMORS' named entity 'RAT' named entity 'FOCI' named entity 'LIVER' named entity 'FOUND' named entity 'FORMATION' named entity 'CORRELATION' named entity 'Q-PCR' named entity '10 WEEKS' named entity 'CONFIRMED BY' named entity 'DOSE' covid:arg/7440e73586a86e38a773cb529bca7ffef7a1afb0 named entity 'OUR' named entity 'CK18' named entity 'CYTOCHROME' named entity 'LEADING' named entity 'HEPATOCARCINOGENESIS' named entity 'CYTOKERATINS' named entity 'DATA' named entity 'REAL-TIME' named entity 'HISTONE' named entity 'ELEVATION' named entity 'ASSOCIATED WITH' named entity 'OVEREXPRESSION' named entity 'FORM' named entity 'GST-P' named entity 'MULTIPLICITY' named entity 'DIETHYLNITROSAMINE' named entity 'PROTEINS' named entity 'NORMAL' named entity 'TRANSFORMATION' named entity 'CONCLUSION' named entity 'SCREENING' named entity 'DRIVE' named entity 'OVEREXPRESSION' named entity 'GST-P' named entity 'COMPLEX FORMATION' named entity 'CYTOKERATIN 8' named entity 'PROTEINCHIP' named entity 'MRNAS' named entity 'DETECTED' named entity 'COMPLEXES' named entity 'IONIZATION' named entity 'DUE TO' named entity 'FOLLOWED BY' named entity 'STRONG' named entity 'NEOPLASTIC TRANSFORMATION' named entity 'TIME-OF-FLIGHT MASS SPECTROMETRY' named entity 'FOCI' named entity 'HEPATOCELLULAR CARCINOMAS' named entity 'GLUTATHIONE S-TRANSFERASE' named entity 'LARGE' named entity 'INTERMEDIATE FILAMENT' named entity 'ENHANCED' named entity 'HEPATOCELLULAR CARCINOMAS' named entity 'PHENOBARBITAL' named entity 'SIZE' named entity 'TYPE 2' named entity 'SIGNIFICANT' named entity 'CK8' named entity 'CELL PROLIFERATION' named entity 'COMPLEX FORMATION' named entity 'POSITIVE' named entity 'PROTEOME' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'CYTOKERATIN 8' named entity 'OBSERVED' named entity 'PROFOUND' named entity 'RATS'

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