About: Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients
Creator	Merle, Uta Altamura, Sandro Hippchen, Theresa Muckenthaler, Martina
Source	MedRxiv
abstract	Background: Iron metabolism might play a crucial role in cytokine release syndrome in COVID-19 patients. Therefore we assessed iron metabolism markers in COVID-19 patients for their ability to predict disease severity. Methods: COVID-19 patients referred to the Heidelberg University Hospital were retrospectively analyzed. Patients were divided into outpatients (cohort A, n=204), inpatients (cohort B, n=81), and outpatients later admitted to hospital because of health deterioration (cohort C, n=23). Results: Iron metabolism parameters were severely altered in patients of cohort B and C compared to cohort A. In multivariate regression analysis including age, gender, CRP and iron-related parameters only serum iron and ferritin were significantly associated with hospitalization. ROC analysis revealed an AUC for serum iron of 0.894 and an iron concentration <6micromol/l as the best cutoff-point predicting hospitalization with a sensitivity of 94.7% and a specificity of 67.9%. When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Unexpectedly, serum iron levels poorly correlate with hepcidin. Conclusion: We conclude that measurement of serum iron can help predicting the severity of COVID-19. The differences in serum iron availability observed between the low and high oxygen demand group suggest that disturbed iron metabolism likely plays a causal role in the pathophysiology leading to lung injury.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.1101/2020.06.26.20140525
has license	medrxiv
sha1sum (hex)	7424b872bb4fd73021ef0208d0922ad63e0bd57e
schema:url	https://doi.org/10.1101/2020.06.26.20140525
resource representing a document's title	Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients
resource representing a document's body	covid:7424b872bb4fd73021ef0208d0922ad63e0bd57e#body_text
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