About: H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice

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About: H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice
Creator	Cao, Yongchang Xue, Chunyi Liu, Yuan Zhang, Yun Gong, Lang Qin, Jianru Peng, Ouyang Shen, Xiaoting
Source	Elsevier; Medline; PMC
abstract	Abstract Influenza A H7N9 virus has caused five outbreak waves of human infections in China since 2013 and posed a dual challenge to public health and poultry industry. There is an urgent need to develop an effective vaccine to reduce its pandemic potential. In the present study, we evaluated the biochemical characteristics and immunogenicity of two H7 virus-like particles (VLPs) composed of the matrix 1 (M1) and hemagglutinin of wild-type (HA-WT) or hemagglutinin of whose transmembrane domain replaced by that from H3N2 subtype (HA-TM). H7 VLPs-WT and H7 VLPs-TM could assemble and release into the supernatant of Sf9 cells and they had similar morphological characteristics. However, compared to H7 VLPs-WT, H7 VLPs-TM had more trimeric HA proteins and could better resist thermal changes. In mice H7 VLPs-TM induced higher titers of HI, IgG, IgG2a and IFN-γ, and provided better protection against homologous and heterologous H7N9 viruses (no matter belonging to Yangtze River Delta or Pearl River Delta) challenge with less weight loss and higher survival rate. In summary, H7 VLPs-TM represents a potential strategy for the development of H7N9 vaccines.
has issue date	2018-08-09(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2018.07.004
bibo:pmid	30037418
has license	els-covid
sha1sum (hex)	741c0b8cf7f5d45eca794f1b1980278799608895
schema:url	https://doi.org/10.1016/j.vaccine.2018.07.004
resource representing a document's title	H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice
has PubMed Central identifier	PMC7115656
has PubMed identifier	30037418
schema:publication	Vaccine
resource representing a document's body	covid:741c0b8cf7f5d45eca794f1b1980278799608895#body_text
is schema:about of	named entity 'HOMOLOGOUS' named entity 'BROAD' named entity 'belonging' named entity 'mice' named entity 'cells' named entity 'matrix' named entity 'mice' named entity 'PROTECTION' named entity 'H3N2' named entity 'TRANSMEMBRANE DOMAIN' named entity 'POULTRY INDUSTRY' named entity 'INFECTIONS' named entity 'MORPHOLOGICAL' named entity 'SF9 CELLS' named entity 'MATTER' named entity 'REPLACED BY' named entity 'CAUSED' named entity 'PUBLIC HEALTH' named entity 'WILD-TYPE' named entity 'H3N2 SUBTYPE' named entity 'IFN' named entity 'SIMILAR' named entity 'MATRIX' named entity 'HUMAN' named entity 'INDUCED' named entity 'VIRUS' named entity 'STUDY' named entity 'VACCINES' named entity 'IGG2A' named entity 'OUTBREAK' named entity 'HEMAGGLUTININ' named entity 'CONTAINING' named entity 'INDUCE' named entity 'VIRUS-LIKE PARTICLES' named entity 'MICE' named entity 'NEED' named entity 'VIRUSES' named entity 'TRANSMEMBRANE DOMAIN' named entity 'YANGTZE RIVER DELTA' named entity 'HETEROLOGOUS' named entity 'VACCINE' named entity 'MICE' named entity 'HIGHER' named entity 'STRATEGY' named entity 'BETTER' named entity 'VIRUS-LIKE PARTICLES' named entity 'PROTEINS' named entity 'DUAL' named entity 'PEARL RIVER DELTA' named entity 'URGENT' named entity 'EFFECTIVE' named entity 'SUMMARY' named entity 'EVALUATED' named entity 'ASSEMBLE' named entity 'POTENTIAL' named entity 'H7N9' named entity 'BIOCHEMICAL' named entity 'COMPOSED OF' named entity 'CHARACTERISTICS' named entity 'CHALLENGE' named entity 'PANDEMIC' named entity 'SURVIVAL RATE' named entity 'BELONGING' named entity 'IGG' named entity 'DEVELOPMENT' named entity 'TO REDUCE' named entity 'IMMUNOGENICITY' named entity 'HETEROLOGOUS' named entity 'WAVES' named entity 'HEMAGGLUTININ' named entity 'CHANGES' named entity 'SUPERNATANT' named entity 'PROTECTION' named entity 'WEIGHT LOSS'

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