About: MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection

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About: MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection
Creator	Huang, Y Li, S Liu, H Tang, Y Wei, B
Source	Medline; PMC
abstract	Viral infection induces innate immunity and apoptosis. Apoptosis is an effective means to sacrifice virus-infected host cells and therefore restrict the spread of pathogens. However, the underlying mechanisms of this process are still poorly understood. Here, we show that the mitochondrial antiviral signaling protein (MAVS/VISA/Cardif/IPS-1) is critical for SeV (Sendai virus)-induced apoptosis. MAVS specifically activates c-Jun N-terminal kinase 2 (JNK2) but not other MAP kinases. Jnk2−/− cells, but not Jnk1−/− cells, are unable to initiate virus-induced apoptosis and SeV further fails to trigger apoptosis in MAPK kinase 7 (MKK7) knockout (Mkk7−/−) cells. Mechanistically, MAVS recruits MKK7 onto mitochondria via its 3D domain, which subsequently phosphorylates JNK2 and thus activates the apoptosis pathway. Consistently, Jnk2−/− mice, but not Jnk1−/− mice, display marked inflammatory injury in lung and liver after viral challenge. Collectively, we have identified a novel signaling pathway, involving MAVS-MKK7-JNK2, which mediates virus-induced apoptosis and highlights the indispensable role of mitochondrial outer membrane in host defenses.
has issue date	2014-03-20(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1004020
bibo:pmid	24651600
has license	cc-by
sha1sum (hex)	740523d9e53ac786c0a45c790320c219cd0031a4
schema:url	https://doi.org/10.1371/journal.ppat.1004020
resource representing a document's title	MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection
has PubMed Central identifier	PMC3961361
has PubMed identifier	24651600
schema:publication	PLoS Pathog
resource representing a document's body	covid:740523d9e53ac786c0a45c790320c219cd0031a4#body_text
is schema:about of	named entity 'Sendai' named entity 'activates' named entity 'SeV' named entity 'MKK7' named entity 'VIRAL INFECTION' named entity 'MKK7' named entity 'INVOLVING' named entity 'PROCESS' named entity 'MEDIATES' named entity 'POORLY' named entity 'INDISPENSABLE' named entity 'PROTEIN ' named entity 'MITOCHONDRIA' named entity 'JNK2' named entity 'PATHOGENS' named entity 'CRITICAL' covid:arg/740523d9e53ac786c0a45c790320c219cd0031a4 named entity 'MECHANISMS' named entity 'DOMAIN' named entity 'INNATE IMMUNITY' named entity 'FAILS' named entity 'HOST' named entity 'SIGNALING PATHWAY' named entity 'MAVS' named entity 'UNDERSTOOD' named entity 'VIRAL INFECTION' named entity 'SACRIFICE' named entity 'INJURY' named entity 'CHALLENGE' named entity 'MAPK KINASE' named entity 'KNOCKOUT' named entity 'APOPTOTIC SIGNALING PATHWAY' named entity 'JNK2' named entity 'NOVEL' named entity 'HAVE' named entity 'LIVER' named entity 'DISPLAY' named entity 'BUT' named entity 'ITS' named entity 'IDENTIFIED' named entity 'VIRUS' named entity 'MAP KINASES' named entity 'MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN' named entity 'MKK7' named entity 'MITOCHONDRIAL OUTER MEMBRANE' named entity 'INFECTED HOST' named entity 'CELLS' named entity 'INITIATE' named entity 'RESTRICT' named entity 'UNDERLYING' named entity 'NOVEL' named entity 'APOPTOSIS' named entity 'VIRAL' named entity 'ROLE' named entity 'HOST CELLS' named entity 'INFLAMMATORY' named entity 'MICE' named entity 'MARKED' named entity 'MEANS' named entity 'SEV' named entity 'MAVS' named entity 'EFFECTIVE' named entity 'C-JUN N-TERMINAL KINASE 2' named entity 'TRIGGER' named entity 'LUNG' named entity 'ACTIVATES' named entity 'HERE' named entity 'SPREAD' named entity 'INDUCED' named entity 'apoptosis' named entity 'immunity' named entity 'MAVS' named entity 'MAVS' named entity 'inflammatory' named entity 'defenses' named entity 'JNK2' named entity 'apoptosis'

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