About: Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology

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About: Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology
Creator	Hildebrand, F Marzi, I Mörs, K Perl, M Relja, B Taraki, R Teuben, M Wagner, N Wutzler, S
Source	PMC
abstract	BACKGROUND: Major trauma patients (TP) developing imbalanced immune response are at high risk for infectious post-injury complications including pneumonia. Neutrophils play a central role in the host defense against bacteria and thereby pathogenesis of infections. While there are numerous studies about neutrophil function after trauma, data about their biology in patients who suffer from pneumonia following trauma are sparse. Here, we studied the effect of serum isolated from patients who do and do not develop infection (inf.) on the biology of neutrophils from healthy volunteers. METHODS: Sera samples from eighteen TP with an injury severity score above 16 were obtained. Nine patients were grouped to no inf. group (TP without pneumonia), and nine to inf. group (TP with pneumonia). Samples were obtained at admission to emergency department (ED), a day prior pneumonia diagnosis (1 d prior inf) or at the day of diagnosis (1 d prior inf). Samples from the equal post-injury days in the corresponding no inf. group were used. Neutrophils from nine healthy volunteers were isolated. Effects for sera isolated from infected and non-infected patients on neutrophil biology were analyzed. Migratory capacity of neutrophils towards TP’s serum, their CD11b and CD62L membrane receptor expression and oxidative burst activity after stimulation with TP’s serum were determined and compared between groups. RESULTS: Migratory capacity of neutrophils was significantly increased after trauma and persisted during the study period. CD11b expression in all groups was significantly increased. CD62L expression decreased generally in samples from ED and recovered later to baseline. Stratifying no inf. and inf. groups showed significantly decreased migratory capacity, increased CD11b and significantly decreased CD62L expression in the no inf. group. These differences persisted during the complete observational period. ROS production was strongly reduced in the no inf. group compared to the inf. group at later experimental time points. CONCLUSIONS: This data indicate that patients at risk for pneumonia development have differentially and early activated neutrophils following trauma compared to patients who are not at risk for post-injury complication. Studies about the differential biology of neutrophils and their immediately after trauma modified activity depending on the post-injury clinical course are warranted, and may deliver predictive or even therapeutic strategies to control inflammation.
has issue date	2016-12-01(xsd:dateTime)
bibo:doi	10.1186/s12890-016-0329-7
bibo:pmid	27905913
has license	cc-by
sha1sum (hex)	73e9bd52cada33801857715315bac4b22ddbf5c8
schema:url	https://doi.org/10.1186/s12890-016-0329-7
resource representing a document's title	Sera from severe trauma patients with pneumonia and without infectious complications have differential effects on neutrophil biology
has PubMed Central identifier	PMC5131406
has PubMed identifier	27905913
schema:publication	BMC Pulm Med
resource representing a document's body	covid:73e9bd52cada33801857715315bac4b22ddbf5c8#body_text
is schema:about of	named entity 'ROLE' named entity 'DEVELOPMENT' named entity 'MEMBRANE RECEPTOR' named entity 'PNEUMONIA' named entity 'GROUPED' named entity 'RESULTS' named entity 'METHODS' named entity 'COMPARED' named entity 'DO NOT' named entity 'GROUPS' named entity 'NEUTROPHILS' named entity 'NUMEROUS' named entity 'RECEPTOR EXPRESSION' named entity 'THERAPEUTIC' named entity 'OXIDATIVE BURST' named entity 'PRODUCTION' named entity 'EXPERIMENTAL' named entity 'DETERMINED' named entity 'INJURY' named entity 'STRATEGIES' named entity 'FUNCTION' named entity 'SUFFER' named entity 'EFFECT' named entity 'THEIR' named entity 'PLAY' named entity 'EARLY' named entity 'SPARSE' named entity 'pneumonia' named entity 'pneumonia' named entity 'serum' named entity 'serum' named entity 'neutrophils' named entity 'host defense' named entity 'inflammation' named entity 'serum' named entity 'CD62L' named entity 'oxidative burst' named entity 'pneumonia' named entity 'blunt trauma' named entity 'pneumonia' named entity 'pneumonia' named entity 'CD62L' named entity 'pneumonia' named entity 'neutrophils' named entity 'neutrophils' named entity 'neutrophils' named entity 'Sarstedt' named entity 'Hazeldine' named entity 'ligands' named entity 'serum' named entity 'blood samples' named entity 'neutrophils' named entity 'blunt trauma' named entity 'Germany' named entity 'neutrophils' named entity 'neutrophils' named entity 'neutrophils' named entity 'pneumonia' named entity 'CD62L' named entity 'stroke' named entity 'Sarstedt' named entity 'serum' named entity 'flow cytometry' named entity 'ISS' named entity 'infection' named entity 'CD62L' named entity 'upper chamber' named entity 'Neutrophils' named entity 'control group' named entity 'abbreviated injury scale' named entity 'neutrophil' named entity 'serum samples' named entity 'chemotherapy'

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