About: In vitro protective efficacy of Lithium chloride against Mycoplasma hyopneumoniae infection

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About: In vitro protective efficacy of Lithium chloride against Mycoplasma hyopneumoniae infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro protective efficacy of Lithium chloride against Mycoplasma hyopneumoniae infection
Creator	Ishag, Hassan Feng, Zhi-Xin Liu, Mao-Jun Shao, Guo-Qing Wu, Yu-Zi Xiong, Qi-Yan Yang, Ruo-Song
topic	covid:73a91f451932c3bda69ff4a9605d327c1106ed78#this
Source	Elsevier; Medline; PMC
abstract	Abstract Mycoplasma hyopneumoniae (M. hyopneumoniae) infection affects the swine industry. Lithium chloride (LiCl), is a drug used to treat bipolar disorder and has also shown activity against bacterial and viral infections. Herein, we evaluated the antibacterial activity of LiCl on PK-15 cells infected with M. hyopneumoniae. Incubation of LiCl (40mM) with cells for 24h, did not significantly affect the cell viability. The qRT–PCR showed ~80% reduction in M. hyopneumoniae genome when LiCl added post-infection. A direct effect of LiCl on bacteria was also observed. However, treatment of cells with LiCl prior infection, does not protect against the infection. Anti-bacterial activity of LiCl was further confirmed by IFA, which demonstrated a reduction in the bacterial protein. With 40mM LiCI, the apoptotic cell death, production of nitric oxide and superoxide anion induced by M. hyopneumoniae, were prevented by ~80%, 60% and 58% respectively. Moreover, caspase-3 activity was also reduced (82%) in cells treated with 40mM LiCl. LiCl showed activity against various strains of M. hyopneumoniae examined in our study. Collectively, our data showed that LiCl inhibited the infection of M. hyopneumoniae through anti-apoptotic mechanism.
has issue date	2016-06-30(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2016.03.013
bibo:pmid	27234543
has license	els-covid
sha1sum (hex)	73a91f451932c3bda69ff4a9605d327c1106ed78
schema:url	https://doi.org/10.1016/j.rvsc.2016.03.013
resource representing a document's title	In vitro protective efficacy of Lithium chloride against Mycoplasma hyopneumoniae infection
has PubMed Central identifier	PMC7111794
has PubMed identifier	27234543
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:73a91f451932c3bda69ff4a9605d327c1106ed78#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/73a91f451932c3bda69ff4a9605d327c1106ed78
is schema:about of	named entity 'IN VITRO' named entity 'viral infections' named entity 'LiCl' named entity 'evaluated' named entity 'LiCl' named entity 'cell' named entity 'INFECTION' named entity 'BACTERIA ' named entity 'INCUBATION' named entity 'INDUSTRY' named entity 'TREAT' named entity 'ACTIVITY' named entity 'IS A' named entity 'IFA' named entity 'GENOME' named entity 'EVALUATED' named entity 'ADDED' named entity 'EFFICACY' named entity 'MYCOPLASMA HYOPNEUMONIAE' named entity 'CELL VIABILITY' named entity 'POST' named entity 'CONFIRMED BY' named entity 'EFFECT' named entity 'OBSERVED' named entity 'REDUCTION' named entity 'LITHIUM CHLORIDE' named entity 'ANTIBACTERIAL' named entity 'DOES NOT' named entity 'DIRECT' named entity 'MYCOPLASMA HYOPNEUMONIAE' named entity 'INFECTION' named entity 'VIRAL INFECTIONS' named entity 'SWINE' named entity 'AFFECT' named entity 'QRT-PCR' named entity 'INFECTED' named entity 'BIPOLAR DISORDER' named entity '80%' named entity 'LITHIUM CHLORIDE' named entity 'BACTERIAL PROTEIN' named entity 'PRIOR' named entity 'CELLS' named entity 'DID' named entity 'TREATMENT' named entity 'DRUG USED' named entity 'BACTERIAL' covid:arg/73a91f451932c3bda69ff4a9605d327c1106ed78 named entity 'cells' named entity 'bacterial' named entity 'affect' named entity 'cells' named entity 'In vitro' named entity 'Lithium chloride' named entity 'swine' named entity 'Mycoplasma hyopneumoniae' named entity 'Lithium chloride' named entity 'prior' named entity 'qRT-PCR' named entity 'Mycoplasma hyopneumoniae' named entity 'centrifuged' named entity 'M. hyopneumoniae' named entity 'PEP' named entity 'p97' named entity 'M. hyopneumoniae' named entity 'pro-apoptotic' named entity 'LiCl' named entity 'LiCl' named entity 'Bax' named entity 'mitochondrial dysfunction' named entity 'LiCl' named entity 'cell types' named entity 'p53' named entity 'LPS'

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