About: Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis

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About: Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
Creator	Hofmann-Lehmann, Regina Novacco, Marilisa Sugiarto, Sarah Meli, Marina Pereira, Sandro De Miranda Id, Monteiro Dib, Isabella Gremião, Ferreira Guerino Dos Reis, Rica Helena, Luisa Menezes, Rodrigo Tima Conceiç Ão-Silva, Fá
Source	Medline; PMC
abstract	Feline sporotrichosis due to Sporothrix brasiliensis is frequently severe and often correlated to zoonotic transmission. Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) cause immunodeficiency in cats; no association has been identified with critical cases of sporotrichosis. Moreover, the cytokine profile in Sporothrix-infected cats and a potential impact of retrovirus co-infections on their immunity is unknown. This study assessed immunological parameters in cats with sporotrichosis with and without FIV or FeLV co-infection. FeLV infection was detected by antigen ELISA and by provirus PCR. FIV infection was investigated through ELISA and Western blot. Cytokine transcription (IFN-γ, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-α) was quantified using RT-qPCR and lymphocyte subpopulations (CD4, CD8, CD5 and CD21) were assessed by flow cytometry. Thirty cats with sporotrichosis were recruited to the study, including three FIV-positive and five FeLV-positive (progressive infection) cats. One cat with regressive FeLV infection was excluded from statistics. In comparison to retrovirus-negative cats, FIV-positive cats and FeLV-positive cats had higher IL-10 levels, FeLV-positive cats had lower IL-4 levels and FIV-positive cats had lower IL-12 levels and a lower CD4+/CD8+ ratio. Remarkably, all cats with poor general condition were FeLV (progressive infection) or FIV-positive, but the retrovirus status was not associated with the sporotrichosis treatment length or outcome. The immunological changes and the more severe clinical presentation observed in cats with retrovirus co-infections encourage future prospective studies that address the impact of these changes on prognostic determinants of feline sporotrichosis and the development of new therapy strategies that control disease spread.
has issue date	2018-11-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0207644
bibo:pmid	30500849
has license	cc-by
sha1sum (hex)	7387ab0ad7fdb62b372043fc912931583e5c7af0
schema:url	https://doi.org/10.1371/journal.pone.0207644
resource representing a document's title	Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
has PubMed Central identifier	PMC6267967
has PubMed identifier	30500849
schema:publication	PLoS One
resource representing a document's body	covid:7387ab0ad7fdb62b372043fc912931583e5c7af0#body_text
is schema:about of	named entity 'retrovirus' named entity 'SPOROTRICHOSIS' named entity 'CATS' named entity 'IMMUNOLOGICAL' named entity 'CO-INFECTION' named entity 'RETROVIRUS' named entity 'PARAMETERS' named entity 'FELINE' named entity 'CHANGES' named entity 'RELATED' named entity 'feline' named entity 'retrovirus' named entity 'infection' named entity 'experimental models' named entity 'sporotrichosis' named entity 'leukocyte' named entity 'programmed cell death protein 1' named entity 'flow cytometry' named entity 'FeLV' named entity 'IL-10' named entity 'cDNA' named entity 'FIV' named entity 'glycoprotein' named entity 'IL-10' named entity 'infection' named entity 'FeLV' named entity 'transcription' named entity 'co-infection' named entity 'supernatant' named entity 'IL-10' named entity 'IL-12' named entity 'provirus' named entity 'Darmstadt' named entity 'retrovirus' named entity 'RT-qPCR' named entity 'high levels' named entity 'sporotrichosis' named entity 'FeLV' named entity 'Fisher's exact test' named entity 'high levels' named entity 'interferon-γ' named entity 'anticoagulants' named entity 'dehydration' named entity 'FeLV' named entity 'coinfection' named entity 'Tregs' named entity 'sporotrichosis' named entity 'Sporothrix' named entity 'sporotrichosis' named entity 'p27' named entity 'retrovirus' named entity 'upregulation' named entity 'Western blot' named entity 'cytokine' named entity 'Cellular immunity' named entity 'FeLV' named entity 'qPCR' named entity 'mycosis' named entity 'retrovirus' named entity 'heparin' named entity '0.01' named entity 'FIV' named entity 'positive control' named entity 'Switzerland' named entity 'CD8+' named entity 'TaqMan' named entity 'sporotrichosis' named entity 'flow cytometer' named entity 'FeLV' named entity 'mucosa'

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