About: Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome
Creator	Yuan, Wanzhe Guo, Rongli He, Kongwang Li, Bin Mao, Aihua Yu, Zhengyu Fan, Baochao Xiao, Qi Jiao, Dian Pang, Fengjiao Zhao, Pandeng Zhao, Xiaona
Source	Medline; PMC
abstract	Outbreaks of porcine epidemic diarrhoea virus (PEDV) have caused great economic losses to the global pig industry. PEDV strains with variants in the spike (S) gene have been reported in several countries. To better understand the molecular epidemiology and genetic diversity of PEDV field isolates, in this study, we characterised the complete genome sequence of a novel PEDV variant JSCZ1601 from a outbreak in China in 2016. The PEDV isolate was 28,033 nucleotides (nt) in length without the polyadenylated sequences. Phylogenetic analysis based on the full-length genome sequence of JSCZ1601 grouped it with the pandemic variants determined post-2010 into group 2 (G2). However, the S gene of JSCZ1601 formed a new subgroup separated from the subgroups containing the other G2 strains. Comparative analysis of the amino acids encoded by the S genes revealed the N-terminal of the deduced JSCZ1601 S protein had a novel two-amino-acid deletion (N58 and S59) compared with all identified genogroups. Further, compared with the reference strains, a ‘G’ insertion was detected in the 5′ terminal of the 5′UTR of the JSCZ1601. The animal experiment revealed that this strain was high pathogenic to neonatal pigs. Taken together, a PEDV strain with the new molecular characterizations and phylogenies was found in mainland China. It is necessary to strengthen the monitoring of PEDV variations.
has issue date	2017-03-09(xsd:dateTime)
bibo:doi	10.1038/srep44209
bibo:pmid	28276526
has license	cc-by
sha1sum (hex)	7360f5cfdd468aea794a9eb68291950862c8fcb0
schema:url	https://doi.org/10.1038/srep44209
resource representing a document's title	Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome
has PubMed Central identifier	PMC5343579
has PubMed identifier	28276526
schema:publication	Sci Rep
resource representing a document's body	covid:7360f5cfdd468aea794a9eb68291950862c8fcb0#body_text
is schema:about of	named entity 'China' named entity 'neonatal' named entity 'nucleotides' named entity 'polyadenylated' named entity 'strains' named entity 'phylogenies' named entity 'determined' named entity 'The animal' named entity 'amino acids' named entity 'Genome' covid:arg/7360f5cfdd468aea794a9eb68291950862c8fcb0 named entity 'field' named entity 'subgroup' named entity 'revealed' named entity 'Phylogenetic analysis' named entity 'high' named entity 'compared' named entity 'experiment' named entity 'complete' named entity 'gene' named entity 'gene' named entity 'animal experiment' named entity 'China' named entity 'N-terminal' named entity 'genetic diversity' named entity 'genome sequence' named entity 'S protein' named entity 'phylogenetic tree' named entity 'inocula' named entity 'glycoprotein' named entity 'vomiting' named entity 'nucleotide' named entity 'amino acid sequences' named entity 'transcriptional regulation' named entity 'virulent' named entity 'virus shedding' named entity 'mainland China' named entity 'amino acid' named entity 'database' named entity 'China' named entity 'China' named entity 'gene' named entity 'GraphPad Prism' named entity 'RNA' named entity 'Changzhou' named entity 'antibody' named entity '5′ UTR' named entity 'severe diarrhoea' named entity 'virulent' named entity 'vector' named entity 'severe diarrhoea' named entity 'genomic sequence' named entity 'transcription' named entity 'pig' named entity 'pathogenicity' named entity 'Jukes-Cantor' named entity 'viral particles' named entity 'Phylogenetic trees' named entity 'coronaviruses' named entity 'genetic characteristics' named entity 'virulence' named entity 'subgenomic mRNA' named entity 'tissue sample' named entity 'viral RNA' named entity 'viral entry' named entity 'coronavirus' named entity 'amino acids' named entity 'Carlsbad, CA' named entity 'amino acid' named entity 'cloned'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software