About: Mucosal and systemic immune responses elicited by recombinant Lactococcus lactis expressing a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Mucosal and systemic immune responses elicited by recombinant Lactococcus lactis expressing a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mucosal and systemic immune responses elicited by recombinant Lactococcus lactis expressing a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis
Creator	Adib, Minoo Ajdary, Soheila Bahrami, Fariborz Torkashvand, Ali
Source	Elsevier; Medline; PMC
abstract	Abstract We constructed a food-grade expression system harboring a F1S1 fusion protein of Bordetella pertussis to be produced in Lactococcus lactis NZ3900 as a new oral vaccine model against whooping cough, caused by B. pertussis. F1S1 was composed of N-terminally truncated S1 subunit of pertussis toxin and type I immunodominant domain of filamentous hemagglutinin which are both known as protective immunogens against pertussis. The recombinant L. lactis was administered via oral or intranasal routes to BALB/c mice and the related specific systemic and mucosal immune responses were then evaluated. The results indicated significantly higher levels of specific IgA in the lung extracts and IgG in sera of mucosally-immunized mice, compared to their controls. It was revealed that higher levels of IgG2a, compared to IgG1, were produced in all mucosally-immunized mice. Moreover, immunized mice developed Th1 responses with high levels of IFN-γ production by the spleen cells. These findings provide evidence for L. lactis to be used as a suitable vehicle for expression and delivery of F1S1 fusion protein to mucosa and induction of appropriate systemic and mucosal immune responses against pertussis.
has issue date	2018-07-31(xsd:dateTime)
bibo:doi	10.1016/j.micpath.2018.05.008
bibo:pmid	29738814
has license	els-covid
sha1sum (hex)	72c8c02249b7473c39acd72dc9bdad3d99d59ea4
schema:url	https://doi.org/10.1016/j.micpath.2018.05.008
resource representing a document's title	Mucosal and systemic immune responses elicited by recombinant Lactococcus lactis expressing a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis
has PubMed Central identifier	PMC7125623
has PubMed identifier	29738814
schema:publication	Microbial Pathogenesis
resource representing a document's body	covid:72c8c02249b7473c39acd72dc9bdad3d99d59ea4#body_text
is schema:about of	named entity 'LACTOCOCCUS LACTIS' named entity 'pertussis' named entity 'levels' named entity 'routes' named entity 'subunit' named entity 'immune responses' named entity 'B. pertussis' named entity 'MUCOSAL' named entity 'MICE' named entity 'CELLS' named entity 'PROTEIN ' named entity 'HIGHER' named entity 'HARBORING' named entity 'ORAL' named entity 'LEVELS' named entity 'EXTRACTS' named entity 'RELATED' named entity 'SPLEEN' named entity 'PERTUSSIS' named entity 'INDICATED' named entity 'NEW' named entity 'SYSTEMIC' named entity 'DOMAIN' named entity 'IMMUNE RESPONSES' named entity 'FINDINGS' named entity 'IGG' named entity 'FUSION PROTEIN' named entity 'PERTUSSIS TOXIN' named entity 'IGG2A' named entity 'FILAMENTOUS HEMAGGLUTININ' named entity 'RECOMBINANT' named entity 'PERTUSSIS TOXIN' named entity 'EXPRESSION SYSTEM' named entity 'ADMINISTERED' named entity 'SUBUNIT' named entity 'SYSTEMIC' named entity 'IMMUNE RESPONSES' named entity 'ELICITED BY' named entity 'COMPOSED OF' named entity 'PROTEIN ' named entity 'BORDETELLA PERTUSSIS' named entity 'FILAMENTOUS HEMAGGLUTININ' named entity 'IMMUNIZED' named entity 'PROVIDE' named entity 'CAUSED BY' named entity 'BALB' named entity 'RESULTS' named entity 'MODEL' named entity 'MUCOSA' named entity 'FOOD' named entity 'IFN' named entity 'MUCOSAL' named entity 'DELIVERY' named entity 'EVIDENCE FOR' named entity 'INDUCTION' named entity 'TH1' named entity 'IGG1' named entity 'INTRANASAL' named entity 'THESE' named entity 'LACTOCOCCUS LACTIS' named entity 'REVEALED' named entity 'VEHICLE' named entity 'COMPOSED OF' named entity 'CONSTRUCTED' named entity 'RESPONSES' named entity 'EXPRESSION' named entity 'APPROPRIATE' named entity 'ORAL VACCINE' named entity 'IGA' named entity 'PRODUCTION' named entity 'SPECIFIC' named entity 'RECOMBINANT' named entity 'GRADE' named entity 'EVALUATED' named entity 'FUSION PROTEIN' named entity 'IMMUNOGENS' named entity 'SERA' named entity 'LUNG'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software