About: Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research
Creator	Prinsloo, Gerhard Marokane, Cynthia Street, Renée
source	Elsevier; Medline; PMC
abstract	Abstract Ethnopharmacological relevance The African continent is home to a large number of higher plant species used over centuries for many applications, which include treating and managing diseases such as HIV. Due to the overwhelming prevalence and incidence rates of HIV, especially in sub-Saharan Africa, it is necessary to develop new and affordable treatments. Aim of the study The article provides an extensive overview of the status on investigation of plants from the southern African region with ethnobotanical use for treating HIV or HIV-related symptoms, or the management of HIV. The review also provide an account of the in vitro assays, anti-viral activity and phytochemistry of these plants. Materials and methods Peer-reviewed articles investigating plants with ethnobotanical information for the treatment or management of HIV or HIV-related symptoms from the southern African region were acquired from Science Direct, PubMed central and Google Scholar. The selection criteria was that (1) plants should have a record of traditional/popular use for infectious or viral diseases, HIV treatment or symptoms similar to HIV infection, (2) if not traditionally/popularly used, plants should be closely related to plants with popular use and HIV activity identified by means of in vitro assays, (3) plants should have been identified scientifically, (4) should be native to southern African region and (5) anti-HIV activity should be within acceptable ranges. Results Many plants in Africa and specifically the southern African region have been used for the treatment of HIV or HIV related symptoms and have been investigated suing various in vitro techniques. In vitro assays using HIV enzymes such as reverse transcriptase (RT), integrase (IN) and protease (PR), proteins or cell-based assays have been employed to validate the use of these plants with occasional indication of the selectivity index (SI) or therapeutic index (TI), with only one study, that progressed to in vivo testing. The compounds identified from plants from southern Africa is similar to compounds identified from other regions of the world, and the compounds have been divided into three groups namely (1) flavonoids and flavonoid glycosides, (2) terpenoids and terpenoid glycosides and (3) phenolic acids and their conjugated forms. Conclusions An investigation of the plants from southern Africa with ethnobotanical use for the treatment of HIV, management of HIV or HIV-related symptoms, therefore provide a very good analysis of the major assays employed and the anti-viral compounds and compound groups identified. The similarity in identified anti-viral compounds worldwide should support the progression from in vitro studies to in vivo testing in development of affordable and effective anti-HIV agents for countries with high infection and mortality rates due to HIV/AIDS.
has issue date	2018-01-10(xsd:dateTime)
bibo:doi	10.1016/j.jep.2017.08.005
bibo:pmid	28807850
has license	els-covid
sha1sum (hex)	729f663149bdb9441f3804fa903ba109a418f700
schema:url	https://doi.org/10.1016/j.jep.2017.08.005
resource representing a document's title	Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research
has PubMed Central identifier	PMC7125770
has PubMed identifier	28807850
schema:publication	Journal of Ethnopharmacology
resource representing a document's body	covid:729f663149bdb9441f3804fa903ba109a418f700#body_text
is schema:about of	named entity 'PLANTS' named entity 'SOUTHERN' named entity 'CURRENT' named entity 'AFRICAN' named entity 'DEVELOPMENTS' named entity 'FUTURE' named entity 'PHYTOCHEMISTRY' named entity 'ANTI-HIV ACTIVITY' named entity 'RESEARCH' named entity 'UNAIDS' named entity 'HIV' named entity 'chlorogenic acid' named entity 'CD4' named entity 'Chlorogenic acid' named entity 'colourimetric' named entity 'protease' named entity 'fluorescence resonance energy transfer' named entity 'Viol' named entity 'quercetin' named entity 'southern African' named entity 'transfection' named entity 'southern Africa' named entity 'jejunum' named entity 'HIV' named entity 'cytotoxicity' named entity 'diterpenoids' named entity 'plasmid' named entity 'TNF-a' named entity 'anti-retroviral' named entity 'HIV-1' named entity 'HIV-1' named entity 'Elaeodendron' named entity 'phenolic acids' named entity 'HeLa cells' named entity 'methanol' named entity 'HIV-1' named entity 'HIV' named entity 'southern Africa' named entity 'firefly luciferase' named entity 'HIV' named entity 'Africa' named entity 'viruses' named entity 'recombinant' named entity 'small intestine' named entity 'glycosylation' named entity 'fluorometric detection' named entity 'clinical trial' named entity 'isoquinoline alkaloids' named entity 'southern Africa' named entity 'catechols' named entity 'PubMed central' named entity 'tuberculosis' named entity 'luciferase' named entity 'HIV treatment' named entity 'hydrolysis' named entity 'HIV' named entity '3,5' named entity 'HIV' named entity 'HIV' named entity 'exocytosis' named entity 'HIV/AIDS' named entity 'caffeic acid' named entity 'CCR5' named entity 'HIV' named entity 'AIDS' named entity 'Germany' named entity 'infectious diseases' named entity 'ART' named entity 'enzyme' named entity 'anti-HIV' named entity 'enzyme' named entity 'HIV' named entity 'eukaryotic' named entity 'HIV' named entity 'Ethiopia' named entity 'tyrosinase' named entity 'divalent' named entity 'Infection' named entity 'medicinal plant'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software