About: PBMC transcriptome profiles identifies potential candidate genes and functional networks controlling the innate and the adaptive immune response to PRRSV vaccine in Pietrain pig

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About: PBMC transcriptome profiles identifies potential candidate genes and functional networks controlling the innate and the adaptive immune response to PRRSV vaccine in Pietrain pig Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PBMC transcriptome profiles identifies potential candidate genes and functional networks controlling the innate and the adaptive immune response to PRRSV vaccine in Pietrain pig
Creator	Große-Brinkhaus, Christine Hoelker, Michael Neuhoff, Christiane Schellander, Karl Tesfaye, Dawit Tholen, Ernst Islam, Md Prö Ll, Maren Rony, Sharmin Uddin, Muhammad
topic	covid:7293d0d1c84570d510be54e720daecfcf7a77990#this
Source	PMC
abstract	The porcine reproductive and respiratory syndrome (PRRS) is a devastating viral disease affecting swine production, health and welfare throughout the world. A synergistic action of the innate and the adaptive immune system of the host is essential for mounting a durable protective immunity through vaccination. Therefore, the current study aimed to investigate the transcriptome profiles of peripheral blood mononuclear cells (PBMCs) to characterize the innate and the adaptive immune response to PRRS Virus (PRRSV) vaccination in Pietrain pigs. The Affymetrix gene chip porcine gene 1.0 ST array was used for the transcriptome profiling of PBMCs collected at immediately before (D0), at one (D1) and 28 days (D28) post PRRSV vaccination with three biological replications. With FDR <0.05 and log2 fold change ±1.5 as cutoff criteria, 295 and 115 transcripts were found to be differentially expressed in PBMCs during the stage of innate and adaptive response, respectively. The microarray expression results were technically validated by qRT-PCR. The gene ontology terms such as viral life cycle, regulation of lymphocyte activation, cytokine activity and inflammatory response were enriched during the innate immunity; cytolysis, T cell mediated cytotoxicity, immunoglobulin production were enriched during adaptive immunity to PRRSV vaccination. Significant enrichment of cytokine-cytokine receptor interaction, signaling by interleukins, signaling by the B cell receptor (BCR), viral mRNA translation, IFN-gamma pathway and AP-1 transcription factor network pathways were indicating the involvement of altered genes in the antiviral defense. Network analysis revealed that four network modules were functionally involved with the transcriptional network of innate immunity, and five modules were linked to adaptive immunity in PBMCs. The innate immune transcriptional network was found to be regulated by LCK, STAT3, ATP5B, UBB and RSP17. While TGFß1, IL7R, RAD21, SP1 and GZMB are likely to be predictive for the adaptive immune transcriptional response to PRRSV vaccine in PBMCs. Results of the current immunogenomics study advances our understanding of PRRS in term of host-vaccine interaction, and thereby contribute to design a rationale for disease control strategy.
has issue date	2017-03-09(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0171828
bibo:pmid	28278192
has license	cc-by
sha1sum (hex)	7293d0d1c84570d510be54e720daecfcf7a77990
schema:url	https://doi.org/10.1371/journal.pone.0171828
resource representing a document's title	PBMC transcriptome profiles identifies potential candidate genes and functional networks controlling the innate and the adaptive immune response to PRRSV vaccine in Pietrain pig
has PubMed Central identifier	PMC5344314
has PubMed identifier	28278192
schema:publication	PLoS One
resource representing a document's body	covid:7293d0d1c84570d510be54e720daecfcf7a77990#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/7293d0d1c84570d510be54e720daecfcf7a77990
is schema:about of	named entity 'adaptive response' named entity 'immunity' named entity 'activity' named entity 'collected' named entity 'mRNA translation' named entity 'welfare' named entity 'CONTROLLING' named entity 'IMMEDIATELY' named entity 'TO CHARACTERIZE' named entity 'STUDY' named entity 'INVOLVED' named entity 'PRRS' named entity 'ENRICHED' named entity 'DEFENSE' named entity 'COLLECTED' named entity 'IFN-GAMMA PATHWAY' named entity 'QRT-PCR' named entity 'SYNERGISTIC ACTION' named entity 'PATHWAYS' named entity 'AFFECTING' named entity 'ADAPTIVE IMMUNITY' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'INNATE IMMUNITY' named entity 'INVOLVEMENT' named entity 'STAGE' named entity 'IMMUNOGLOBULIN PRODUCTION' named entity 'HOST' named entity 'VACCINATION' named entity 'IL7R' named entity 'ANTIVIRAL' named entity 'B11' named entity 'MOUNTING' named entity 'TRANSCRIPTOME PROFILING' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME' named entity 'WORLD' named entity 'IMMUNE' named entity 'HEALTH' named entity 'ADAPTIVE IMMUNE RESPONSE' named entity 'RESULTS' named entity 'VIRAL DISEASE' named entity 'CRITERIA' named entity 'VIRUS' named entity 'UBB' named entity 'PIGS' named entity 'AP-1 TRANSCRIPTION FACTOR NETWORK' named entity 'WELFARE' named entity 'SIGNALING' named entity 'TO INVESTIGATE' named entity 'CURRENT' named entity 'INDICATING' named entity 'BIOLOGICAL' named entity 'TRANSCRIPTOME' named entity 'PORCINE' named entity 'FDR' named entity 'GENE ONTOLOGY' named entity 'ONTOLOGY TERMS' named entity 'LOG2' named entity 'NETWORKS' named entity 'INFLAMMATORY RESPONSE' named entity 'DAYS' named entity 'REVEALED' named entity 'ALTERED' named entity 'VALIDATED' named entity 'CYTOKINE-CYTOKINE RECEPTOR INTERACTION' named entity 'FOUND' named entity 'REGULATION OF LYMPHOCYTE ACTIVATION' named entity 'CYTOLYSIS' named entity 'TGF' named entity 'FOLD CHANGE' named entity 'FUNCTIONAL'

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