About: The 19 kDa Mycobacterium tuberculosis Lipoprotein (LpqH) Induces Macrophage Apoptosis through Extrinsic and Intrinsic Pathways: A Role for the Mitochondrial Apoptosis-Inducing Factor

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About: The 19 kDa Mycobacterium tuberculosis Lipoprotein (LpqH) Induces Macrophage Apoptosis through Extrinsic and Intrinsic Pathways: A Role for the Mitochondrial Apoptosis-Inducing Factor Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The 19 kDa Mycobacterium tuberculosis Lipoprotein (LpqH) Induces Macrophage Apoptosis through Extrinsic and Intrinsic Pathways: A Role for the Mitochondrial Apoptosis-Inducing Factor
Creator	Espinosa, Patricia García, Teresa Mancilla, Raúl Sánchez, Alejandro
Source	Medline; PMC
abstract	We describe the association of caspase-dependent and caspase-independent mechanisms in macrophage apoptosis induced by LpqH, a 19 kDa Mycobacterium tuberculosis lipoprotein. LpqH triggered TLR2 activation, with upregulation of death receptors and ligands, which was followed by a death receptor signaling cascade with activation of initiator caspase 8 and executioner caspase 3. In this caspase-mediated phase, mitochondrial factors were involved in loss of mitochondrial transmembrane potential (ΔΨm), release of cytochrome c, and caspase 9 activation. Interestingly, a caspase-independent pathway was also identified; by immunoblot, the mitochondrial apoptosis inducing factor (AIF) was demonstrated in nuclei and cytosol of LpqH-treated macrophages. Confocal microscopy revealed translocation of AIF to the nuclei of the majority of apoptotic cells. These findings emphasize the complex and redundant nature of the macrophage death response to mycobacteria.
has issue date	2012-12-19(xsd:dateTime)
bibo:doi	10.1155/2012/950503
bibo:pmid	23316255
has license	cc-by
sha1sum (hex)	725b175750813a29f16faee9a389ed706eba5ae4
schema:url	https://doi.org/10.1155/2012/950503
resource representing a document's title	The 19 kDa Mycobacterium tuberculosis Lipoprotein (LpqH) Induces Macrophage Apoptosis through Extrinsic and Intrinsic Pathways: A Role for the Mitochondrial Apoptosis-Inducing Factor
has PubMed Central identifier	PMC3536062
has PubMed identifier	23316255
schema:publication	Clin Dev Immunol
resource representing a document's body	covid:725b175750813a29f16faee9a389ed706eba5ae4#body_text
is schema:about of	named entity 'LPQH' named entity 'THESE' named entity 'CASPASE 3' named entity 'TRANSMEMBRANE POTENTIAL' named entity 'EXECUTIONER' named entity 'INDEPENDENT' named entity 'PHASE' named entity 'IMMUNOBLOT' named entity 'DESCRIBE' named entity 'DEATH RECEPTORS' named entity 'MACROPHAGE' named entity 'CELLS' named entity 'SIGNALING CASCADE' named entity 'DEPENDENT' named entity 'NATURE' named entity 'NUCLEI' named entity 'TRANSLOCATION' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'MITOCHONDRIAL' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'EXTRINSIC' named entity 'PATHWAYS' covid:arg/725b175750813a29f16faee9a389ed706eba5ae4 named entity 'APOPTOSIS INDUCING FACTOR' named entity 'MITOCHONDRIAL' named entity 'LIPOPROTEIN' named entity 'AIF' named entity 'A 19' named entity 'INVOLVED' named entity 'MECHANISMS' named entity 'ACTIVATION' named entity 'UPREGULATION' named entity 'LOSS OF' named entity 'PATHWAY' named entity 'KDA' named entity 'CASPASE 8' named entity 'CASPASE 9' named entity 'CASPASE' named entity 'CONFOCAL MICROSCOPY' named entity 'INDUCING' named entity 'ROLE' named entity 'INTRINSIC' named entity 'APOPTOSIS' named entity 'MACROPHAGE APOPTOSIS' named entity 'LIPOPROTEIN' named entity 'FACTOR' named entity 'RELEASE' named entity 'REDUNDANT' named entity 'TRIGGERED' named entity 'IDENTIFIED' named entity 'RESPONSE TO' named entity 'MYCOBACTERIA' named entity 'MAJORITY' named entity 'DEATH RECEPTOR SIGNALING' named entity 'COMPLEX' named entity 'LIGANDS' named entity 'TREATED' named entity 'APOPTOTIC' named entity 'MACROPHAGES' named entity 'FOLLOWED BY' named entity 'CYTOCHROME C' named entity 'REVEALED' named entity 'MACROPHAGE APOPTOSIS' named entity 'FINDINGS' named entity 'MEDIATED' named entity 'CYTOSOL' named entity 'DEATH' named entity 'ASSOCIATION' named entity 'TLR2' named entity 'INITIATOR' named entity 'INDUCED' named entity 'signaling cascade' named entity 'nuclei' named entity 'transmembrane potential' named entity 'cytosol' named entity 'ligands' named entity 'AIF' named entity 'apoptosis'

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