About: Antioxidant effect of angiotensin (1-7) in the protection of pancreatic β cell function

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About: Antioxidant effect of angiotensin (1-7) in the protection of pancreatic β cell function Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antioxidant effect of angiotensin (1-7) in the protection of pancreatic β cell function
Creator	Liu, Chang Wang, Lei Yang, Jin Wang, Ying Zhang, Fen Cao, X
source	Medline; PMC
abstract	It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7) [Ang (1-7)]/Mas axis is a negative regulator of the classical renin-angiotensin system. In order to investigate the antioxidant effect of Ang (1-7) on pancreatic β cells, INS-1 cells were cultured and oxidative stress was induced by treatment with H(2)O(2). Glucose-stimulated insulin secretion (GSIS), the generation of reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and glucose-stimulated calcium (GSCa) responses in β cells were determined following treatment with Ang (1-7). It was observed that H(2)O(2) significantly impaired the insulin secreting function, increased the production of ROS, and also decreased the levels of GSCa and MMP. Pre-treatment with Ang (1-7) alleviated these effects and treatment with A779 [antagonist of Ang (1-7)] prevented the effects of Ang (1-7). Based on these findings, it was concluded that Ang (1-7) can protect pancreatic β cells from oxidative injury and such protection can be blocked by its antagonist A779.
has issue date	2016-07-13(xsd:dateTime)
bibo:doi	10.3892/mmr.2016.5514
bibo:pmid	27430410
has license	cc-by-nc-nd
sha1sum (hex)	723d2ca57cbcc702c68347fb8183376d16d80f1a
schema:url	https://doi.org/10.3892/mmr.2016.5514
resource representing a document's title	Antioxidant effect of angiotensin (1-7) in the protection of pancreatic β cell function
has PubMed Central identifier	PMC4991744
has PubMed identifier	27430410
schema:publication	Mol Med Rep
resource representing a document's body	covid:723d2ca57cbcc702c68347fb8183376d16d80f1a#body_text
is schema:about of	named entity 'CELL FUNCTION' named entity 'OXIDATIVE STRESS' named entity 'STRESS INJURY' named entity 'LEVELS' named entity 'DIABETIC' named entity 'STATE' named entity 'PRE' named entity 'MITOCHONDRIAL MEMBRANE POTENTIAL' named entity 'EFFECT' named entity 'CLASSICAL' named entity 'PRODUCTION' named entity 'BLOCKED' named entity 'GLUCOSE' named entity 'PANCREATIC' named entity 'ANTAGONIST' named entity 'REACTIVE OXYGEN SPECIES' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'AXIS' named entity 'RESULTS' named entity 'FUNCTION' named entity 'renin-angiotensin system' named entity 'β cells' named entity 'ANG' named entity 'induced' named entity 'production' named entity 'blocked' named entity 'MMP' named entity 'INCREASED' named entity 'OBSERVED' named entity 'FINDINGS' named entity 'CULTURED' named entity 'LOCAL' named entity 'ACTIVATED' named entity 'THESE' named entity 'RESPONSES' named entity 'INS-1' named entity 'PROTECTION' named entity 'H 2' named entity 'ITS' named entity 'KNOWN' named entity 'MMP' named entity 'PANCREATIC' named entity 'ANTIOXIDANT' named entity 'B2 CELL' named entity 'EFFECT' named entity 'PROTECTION' named entity 'TO INVESTIGATE' named entity 'BASED' named entity 'OXIDATIVE INJURY' named entity 'FOLLOWING' named entity 'INDUCED' named entity 'GENERATION' named entity 'ANG' named entity 'ROS' named entity 'IS A' named entity 'CELLS' named entity 'STIMULATED' named entity 'INCREASE' named entity 'ANGIOTENSIN' named entity 'DETERMINED' named entity 'ANTIOXIDANT' named entity 'LEVEL' named entity 'ORDER' named entity 'DECREASED' named entity 'IMPAIRED' named entity 'SECRETING' named entity 'INSULIN' named entity 'TREATMENT' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity '2 O' named entity 'NEGATIVE REGULATOR' named entity 'INSULIN SECRETION' named entity 'CALCIUM' covid:arg/723d2ca57cbcc702c68347fb8183376d16d80f1a named entity 'pancreatic' named entity 'level'

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