About: Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup

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About: Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup
Creator	Köllner, Bernd Kammerer, Robert He, Xiaocui Zimmermann, Wolfgang Hänske, Jana Mansfeld, Martin Mißbach, Sophie Mouchantat, Susan
Source	Medline; PMC
abstract	BACKGROUND: Expansions of gene families are predictive for ongoing genetic adaptation to environmental cues. We describe such an expansion of the carcinoembryonic antigen (CEA) gene family in certain bat families. Members of the CEA family in humans and mice are exploited as cellular receptors by a number of pathogens, possibly due to their function in immunity and reproduction. The CEA family is composed of CEA-related cell adhesion molecules (CEACAMs) and secreted pregnancy-specific glycoproteins (PSGs). PSGs are almost exclusively expressed by trophoblast cells at the maternal-fetal interface. The reason why PSGs exist only in a minority of mammals is still unknown. RESULTS: Analysis of the CEA gene family in bats revealed that in certain bat families, belonging to the subgroup Yangochiroptera but not the Yinpterochiroptera subgroup an expansion of the CEA gene family took place, resulting in approximately one hundred CEA family genes in some species of the Vespertilionidae. The majority of these genes encode secreted PSG-like proteins (further referred to as PSG). Remarkably, we found strong evidence that the ligand-binding domain (IgV-like domain) of PSG is under diversifying positive selection indicating that bat PSGs may interact with structurally highly variable ligands. Such ligands might represent bacterial or viral pathogen adhesins. We have identified two distinct clusters of PSGs in three Myotis species. The two PSG cluster differ in the amino acids under positive selection. One cluster was only expanded in members of the Vespertilionidae while the other was found to be expanded in addition in members of the Miniopteridae and Mormoopidae. Thus one round of PSG expansion may have occurred in an ancestry of all three families and a second only in Vespertilionidae. Although maternal ligands of PSGs may exist selective challenges by two distinct pathogens seem to be likely responsible for the expansion of PSGs in Vespertilionidae. CONCLUSIONS: The rapid expansion of PSGs in certain bat species together with selection for diversification suggest that bat PSGs could be part of a pathogen defense system by serving as decoy receptors and/or regulators of feto-maternal interactions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-017-4106-7) contains supplementary material, which is available to authorized users.
has issue date	2017-09-11(xsd:dateTime)
bibo:doi	10.1186/s12864-017-4106-7
bibo:pmid	28893191
has license	cc-by
sha1sum (hex)	71c95bd39c649d3ba3fee28d11be98cd4019de7f
schema:url	https://doi.org/10.1186/s12864-017-4106-7
resource representing a document's title	Recent expansion and adaptive evolution of the carcinoembryonic antigen family in bats of the Yangochiroptera subgroup
has PubMed Central identifier	PMC5594555
has PubMed identifier	28893191
schema:publication	BMC Genomics
resource representing a document's body	covid:71c95bd39c649d3ba3fee28d11be98cd4019de7f#body_text
is schema:about of	named entity 'evidence' named entity 'cluster' named entity 'species' named entity 'CEA' named entity 'genes' named entity 'CEA' named entity 'The' named entity 'pathogen' named entity 'Yangochiroptera' named entity 'structurally' named entity 'The majority' named entity 'Yangochiroptera' covid:arg/71c95bd39c649d3ba3fee28d11be98cd4019de7f named entity 'family' named entity 'minority' named entity 'Vespertilionidae' named entity 'referred' named entity 'genes' named entity 'families' named entity 'gene' named entity 'pathogens' named entity 'subgroup' named entity 'exon' named entity 'CEA' named entity 'gene' named entity 'gene family' named entity 'CEACAM19' named entity 'gene family' named entity 'ITIM' named entity 'galectins' named entity 'CEA' named entity 'CEA' named entity 'Sequence alignments' named entity 'Mya' named entity 'hemochorial placenta' named entity 'likelihood ratio test' named entity 'intestine' named entity 'phylogenetic tree' named entity 'ligands' named entity 'gene families' named entity 'Yinpterochiroptera' named entity 'coding regions' named entity 'genome' named entity 'RNA sequencing' named entity 'Vespertilionidae' named entity 'transmembrane domain' named entity 'tyrosine' named entity 'mammals' named entity 'CEACAM19' named entity 'Chiroptera' named entity 'CEA' named entity 'spleen' named entity 'hemochorial placenta' named entity 'pathogen' named entity 'stop codons' named entity 'PSG II' named entity 'intestine' named entity 'ligand-binding domain' named entity 'diversifying selection' named entity 'transmembrane domain' named entity 'cytoplasmic' named entity 'mammals' named entity 'gene family' named entity 'exon' named entity 'ORF' named entity 'blastn' named entity 'epithelial' named entity 'whole-genome shotgun' named entity 'Laurasiatheria' named entity 'immune cells' named entity 'fetal cells' named entity 'Yangochiroptera' named entity 'ITIM' named entity 'gene family'

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