About: Cytopathy of an infiltrating monocyte lineage during the early phase of infection with murinecoronavirus in the brain

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About: Cytopathy of an infiltrating monocyte lineage during the early phase of infection with murinecoronavirus in the brain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cytopathy of an infiltrating monocyte lineage during the early phase of infection with murinecoronavirus in the brain
Creator	Watanabe, Rihito Taguchi, Fumihiro Ikehara, Yuzuru Kashiwazaki, Hiromi Nomura, Risa Takatsuki, Hanae Watanabe, Mariko
Source	Medline; PMC
abstract	Viral spread during the early stages after infection was compared between a highly neurovirulent mouse hepatitis virus (MHV), JHMV cl‐2 strain (cl‐2), and its low‐virulent mutant, soluble‐receptor‐resistant (srr)7. The infection of cells with srr7 (soluble‐receptor‐resistant mutant 7) is dependent on a known MHV receptor (MHVR), carcinoembryonic cell adhesion molecule 1a, whereas cl‐2 shows MHVR‐independent infection. Initial viral antigens were detected between 12 and 24 h post‐inoculation (p.i) in the infiltrating cells that appeared in the subarachnoidal space of mouse brains infected with viruses. There were no significant differences in the intensity or spread of viral antigens in the inflammatory cells between the two viruses. However, 48 h after infection with cl‐2, viral antigen‐positive cells in the grey matter with the shape of neurons, which do not express MHVR, were detected, while srr7 infection was observed primarily in the white matter. Some of the viral antigen‐positive inflammatory cells found in the subarachnoidal space during the early phase of infection reacted with anti‐F4/80 or anti‐CD11b monoclonal antibodies. Syncytial giant cells (SGCs) expressing viral and CD11b antigens were also detected among these inflammatory cells. These antigen‐positive cells appeared in the subarachnoidal space prior to viral antigen spread into the brain parenchyma, indicating that viral encephalitis starts with the infection of infiltrating monocytes which express MHVR. Furthermore, the observation indicates that viral infection has cytopathic effects on the monocyte lineage, which plays a critical role in innate immunity, leading to the rapid spread of viruses during the early stage of infection.
has issue date	2009-12-28(xsd:dateTime)
bibo:doi	10.1111/j.1440-1789.2009.01082.x
bibo:pmid	20051016
has license	no-cc
sha1sum (hex)	714e8e245eece5af3c70a7b71ae9d6ea2e82e110
schema:url	https://doi.org/10.1111/j.1440-1789.2009.01082.x
resource representing a document's title	Cytopathy of an infiltrating monocyte lineage during the early phase of infection with murinecoronavirus in the brain
has PubMed Central identifier	PMC7194124
has PubMed identifier	20051016
schema:publication	Neuropathology
resource representing a document's body	covid:714e8e245eece5af3c70a7b71ae9d6ea2e82e110#body_text
is schema:about of	named entity 'SUBARACHNOIDAL' named entity 'CYTOPATHIC EFFECTS' named entity 'CD11b' named entity 'antigen' named entity 'innate immunity' named entity 'viral infection' named entity 'monocyte' named entity 'mouse strain' named entity 'methanol' named entity 'goat' named entity 'inbred' named entity 'white matter' named entity 'infection' named entity 'receptor expression' named entity 'infection' named entity 'microglia' named entity 'immune-mediated' named entity 'brain parenchyma' named entity 'primary antibody' named entity 'CD3e' named entity 'infection' named entity 'Phe' named entity 'microglia' named entity 'Charles River' named entity 'viral antigens' named entity 'leukocytes' named entity 'antigens' named entity 'viruses' named entity 'San Diego' named entity 'aseptically' named entity 'mice' named entity 'IgG' named entity 'innate immunity' named entity 'influenza viruses' named entity 'mice' named entity 'influenza virus' named entity 'MHV' named entity 'ICR mice' named entity 'coronavirus' named entity 'infection' named entity 'frontal lobe' named entity 'spleen' named entity 'MHV' named entity 'CD31' named entity 'viral encephalitis' named entity 'virus' named entity 'CNS' named entity 'red pulp' named entity 'CD11b' named entity 'receptor expression' named entity 'astrocytes' named entity 'syncytia' named entity 'RNA' named entity 'encephalomyelitis' named entity 'CD11b' named entity 'Blood vessels' named entity 'inflammatory cells' named entity 'human immunodeficiency virus' named entity 'MHV' named entity 'cytopathic effects' named entity 'viral antigens' named entity 'MAb' named entity 'histological staining' named entity 'antigen' named entity 'monocytes' named entity 'parenchyma' named entity 'viral antigens' named entity 'antigens' named entity 'receptor' named entity 'virion' named entity 'receptor' named entity 'brain parenchyma' named entity 'monocyte' named entity 'inflammatory cells' named entity 'F4/80'

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