About: Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers

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About: Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers
Creator	Liu, Ping Guo, Xiaoquan Hu, Guoliang Cao, Huabin Zhang, Caiying Deng, Guangfu Huang, Qiqi Kuang, Jun Lin, Huayuan Liu, Weilian Zhu, Shuliang Zou, Yuelong
Source	PMC
abstract	To assess relationships between xanthine oxidase (XOD) and nephropathogenic infectious bronchitis virus (NIBV) infection, 240 growing layers (35 days old) were randomly divided into two groups (infected and control) of 120 chickens each. Each chicken in the control and infected group was intranasally inoculated with 0.2 mL sterile physiological saline and virus, respectively, after which serum antioxidant parameters and renal XOD mRNA expression in growing layers were evaluated at 8, 15 and 22 days post-inoculation (dpi). The results showed that serum glutathione peroxidase and superoxide dismutase activities in the infected group were significantly lower than in the control group at 8 and 15 dpi (p < 0.01), while serum malondialdehyde concentrations were significantly higher (p < 0.01). The serum uric acid was significantly higher than that of the control group at 15 dpi (p < 0.01). In addition, the kidney mRNA transcript level and serum activity of XOD in the infected group was significantly higher than that of the control group at 8, 15 and 22 dpi (p < 0.05). The results indicated that NIBV infection could cause the increases of renal XOD gene transcription and serum XOD activity, leading to hyperuricemia and reduction of antioxidants in the body.
has issue date	2015-12-17(xsd:dateTime)
bibo:doi	10.4142/jvs.2015.16.4.423
bibo:pmid	26119168
has license	cc-by-nc
sha1sum (hex)	711ffbd9492fb8100b4c89fea6842c38682e4410
schema:url	https://doi.org/10.4142/jvs.2015.16.4.423
resource representing a document's title	Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers
has PubMed Central identifier	PMC4701734
has PubMed identifier	26119168
schema:publication	J Vet Sci
resource representing a document's body	covid:711ffbd9492fb8100b4c89fea6842c38682e4410#body_text
is schema:about of	named entity 'GROWING' named entity 'POST' named entity 'SERUM' named entity 'EVALUATED' named entity '0.01' named entity 'REDUCTION' named entity 'ACTIVITY' named entity 'GLUTATHIONE PEROXIDASE' named entity 'HYPERURICEMIA' named entity 'GROUP' named entity 'INOCULATION' named entity 'DAYS' named entity 'ANTIOXIDANT' named entity 'KIDNEY' named entity 'INCREASES' named entity 'LEADING' named entity 'RELATIONSHIPS' named entity 'higher' named entity 'infectious bronchitis' named entity 'infected' named entity 'control group' named entity 'infection' named entity 'GROUPS' named entity 'ACTIVITIES' named entity 'LEVEL' named entity 'ELEVATED' covid:arg/711ffbd9492fb8100b4c89fea6842c38682e4410 named entity 'PARAMETERS' named entity 'GENE TRANSCRIPTION' named entity 'CONTROL GROUP' named entity 'ASSESS' named entity '0.05' named entity 'INFECTION' named entity 'LAYERS' named entity 'VIRUS INFECTION' named entity 'RENAL' named entity 'GROWING' named entity 'XANTHINE OXIDASE' named entity 'MRNA TRANSCRIPTION' named entity 'LEVEL' named entity '0.2' named entity 'HIGHER' named entity 'SUPEROXIDE DISMUTASE' named entity 'CAUSE' named entity 'DIVIDED' named entity 'LAYERS' named entity 'OLD' named entity 'INDICATED' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'TRANSCRIPT' named entity 'XANTHINE OXIDASE' named entity 'DPI' named entity 'RENAL' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'MALONDIALDEHYDE' named entity '240' named entity 'SERUM URIC ACID' named entity 'ANTIOXIDANTS' named entity 'INFECTED' named entity 'CONCENTRATIONS' named entity 'LOWER' named entity 'MRNA' named entity 'RESULTS' named entity 'STERILE' named entity '120' named entity 'ADDITION' named entity '28P' named entity 'VIRUS' named entity 'CHICKENS' named entity 'PHYSIOLOGICAL'

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