About: A balanced game: chicken macrophage response to ALV-J infection

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About: A balanced game: chicken macrophage response to ALV-J infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A balanced game: chicken macrophage response to ALV-J infection
Creator	Zhang, Nan Feng, Min Li, Yuanfang Lu, Qiuyuan Shi, Meiqing Sun, Jingchen Xie, Tingting Zhang, Xiquan Zhou, Yaohong
Source	PMC
abstract	Avian leukosis virus subgroup J (ALV-J) infection can cause tumors and immunosuppression in infected chickens. Macrophages play a central role in host defense against invading pathogens. In this study, we discovered an interesting phenomenon: ALV-J replication is weakened from 3 hours post-infection (hpi) to 36 hpi, which was verified using Western blotting and RT-PCR. To further investigate the interaction between ALV-J and macrophages, transcriptome analysis was performed to analyze the host genes’ function in chicken primary monocyte-derived macrophages (MDM). Compared to the uninfected control, 624 up-regulated differentially expressed genes (DEG) and 341 down-regulated DEG at 3 hpi, and 174 up-regulated DEG and 87 down-regulated DEG at 36 hpi were identified in chicken MDM, respectively. ALV-J infection induced strong innate immune responses in chicken MDM at 3 hpi, instead of 36 hpi, according to the analysis results of Gene Ontology and KEGG pathway. Importantly, the host factors, such as up-regulated MIP-3α, IL-1β, iNOS, K60, IRG1, CH25H, NFKBIZ, lysozyme and OASL were involved in the host defense response during the course of ALV-J infection. On the contrary, up-regulated EX-FABP, IL4I1, COX-2, NFKBIA, TNFAIP3 and the Jak STAT pathway inhibitors including CISH, SOCS1 and SOCS3 are beneficial to ALV-J survival in chicken macrophages. We speculated that ALV-J tropism for macrophages helps to establish a latent infection in chicken MDM from 6 to 36 hpi. The present study provides a comprehensive view of the interactions between macrophages and ALV-J. It suggests the mechanisms of defense of chicken macrophages against ALV-J invasion and how ALV-J escape the host innate immune responses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13567-019-0638-y) contains supplementary material, which is available to authorized users.
has issue date	2019-03-06(xsd:dateTime)
bibo:doi	10.1186/s13567-019-0638-y
bibo:pmid	30841905
has license	cc-by
sha1sum (hex)	70da3ee5739197acb1879c1d23606681aaac2e1c
schema:url	https://doi.org/10.1186/s13567-019-0638-y
resource representing a document's title	A balanced game: chicken macrophage response to ALV-J infection
has PubMed Central identifier	PMC6404279
has PubMed identifier	30841905
schema:publication	Vet Res
resource representing a document's body	covid:70da3ee5739197acb1879c1d23606681aaac2e1c#body_text
is schema:about of	named entity 'hpi' named entity 'Gene Ontology' named entity 'NFKBIA' named entity 'lysozyme' named entity 'COX-2' named entity 'hpi' covid:arg/70da3ee5739197acb1879c1d23606681aaac2e1c named entity 'Avian leukosis virus' named entity 'hpi' named entity 'TNFAIP3' named entity 'interactions' named entity 'mechanisms' named entity 'infected' named entity 'defense response' named entity 'investigate' named entity 'downregulated' named entity 'transcriptome' named entity 'escape' named entity 'RT-PCR' named entity 'chicken' named entity 'up-regulated' named entity 'transcriptome analysis' named entity 'Gene Ontology' named entity 'NFKBIA' named entity 'macrophages' named entity 'chicken' named entity 'IL-1β' named entity 'macrophages' named entity 'infection' named entity 'host defense' named entity 'macrophages' named entity 'differentially expressed genes' named entity 'macrophages' named entity 'Avian leukosis virus' named entity 'CISH' named entity 'COX-2' named entity 'TNFAIP3' named entity 'DEG' named entity 'latent infection' named entity 'macrophages' named entity 'control' named entity 'chicken' named entity 'chicken' named entity 'dengue virus' named entity 'hpi' named entity 'down-regulate' named entity 'anti-HIV' named entity 'signaling pathway' named entity 'White Leghorn' named entity 'gene expression' named entity 'EBOV' named entity 'vaccines' named entity 'MDA5' named entity 'ALV' named entity 'RNA' named entity 'hpi' named entity 'hpi' named entity 'protein' named entity 'murine' named entity 'anti-microbial' named entity 'apoptotic' named entity 'RNA' named entity 'monocyte-derived macrophages' named entity 'ALV' named entity 'hpi' named entity 'virus' named entity 'MDM' named entity 'MDM' named entity 'ALV' named entity 'signaling pathway' named entity 'macrophage' named entity 'IL-1' named entity 'chicken'

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