About: Transcriptional profiles of PBMCs from pigs infected with three genetically diverse porcine reproductive and respiratory syndrome virus strains

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About: Transcriptional profiles of PBMCs from pigs infected with three genetically diverse porcine reproductive and respiratory syndrome virus strains Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptional profiles of PBMCs from pigs infected with three genetically diverse porcine reproductive and respiratory syndrome virus strains
Creator	Kuźmak, Jacek Materniak-Kornas, Magdalena Pluta, Aneta Rola-Łuszczak, Marzena Stadejek, Tomasz Katarzyna Podgórska, · Nielsen, ·
Source	Medline; PMC
abstract	Porcine reproductive and respiratory syndrome virus is the cause of reproductive failure in sows and respiratory disease in young pigs, which has been considered as one of the most costly diseases to the worldwide pig industry for almost 30 years. This study used microarray-based transcriptomic analysis of PBMCs from experimentally infected pigs to explore the patterns of immune dysregulation after infection with two East European PRRSV strains from subtype 2 (BOR and ILI) in comparison to a Danish subtype 1 strain (DAN). Transcriptional profiles were determined at day 7 post infection in three tested groups of pigs and analysed in comparison with the expression profile of control group. Microarray analysis revealed differential regulation (> 1.5-fold change) of 4253 and 7335 genes in groups infected with BOR and ILI strains, respectively, and of 12518 genes in pigs infected with Danish strain. Subtype 2 PRRSV strains showed greater induction of many genes, especially those involved in innate immunity, such as interferon stimulated antiviral genes and inflammatory markers. Functional analysis of the microarray data revealed a significant up-regulation of genes involved in processes such as acute phase response, granulocyte and agranulocyte adhesion and diapedesis, as well as down-regulation of genes enrolled in pathways engaged in protein synthesis, cell division, as well as B and T cell signaling. This study provided an insight into the host response to three different PRRSV strains at a molecular level and demonstrated variability between strains of different pathogenicity level. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11033-018-4204-x) contains supplementary material, which is available to authorized users.
has issue date	2018-06-07(xsd:dateTime)
bibo:doi	10.1007/s11033-018-4204-x
bibo:pmid	29882085
has license	cc-by
sha1sum (hex)	70adc25ffcec7b3d1871ea866658c3cd01080f49
schema:url	https://doi.org/10.1007/s11033-018-4204-x
resource representing a document's title	Transcriptional profiles of PBMCs from pigs infected with three genetically diverse porcine reproductive and respiratory syndrome virus strains
has PubMed Central identifier	PMC6156768
has PubMed identifier	29882085
schema:publication	Mol Biol Rep
resource representing a document's body	covid:70adc25ffcec7b3d1871ea866658c3cd01080f49#body_text
is schema:about of	named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'REVEALED' named entity 'HOST RESPONSE' named entity 'PATTERNS' named entity 'PBMCS' named entity 'DIAPEDESIS' named entity 'YEARS' named entity 'CONSIDERED' named entity 'PBMCS' named entity 'USED' named entity 'DANISH' named entity 'MICROARRAY' named entity 'INFECTION' named entity 'COMPARISON' named entity 'SOWS' named entity 'CELL DIVISION' named entity 'INDUCTION' named entity 'DETERMINED' named entity 'PROCESSES' named entity 'RESPIRATORY DISEASE' named entity 'TRANSCRIPTIONAL' named entity 'ANALYSIS' named entity 'DOWN-REGULATION' named entity '2C CELL' named entity 'MOLECULAR' named entity 'ADHESION' named entity 'DIVERSE' named entity 'TRANSCRIPTIONAL' named entity 'ONE OF' named entity 'BASED' named entity 'RESPONSE TO' named entity 'STRAIN' named entity 'GRANULOCYTE' named entity 'STRAINS' named entity 'PIGS' named entity 'SIGNIFICANT' named entity 'ANTIVIRAL' named entity 'INFECTED' named entity 'UP-REGULATION' named entity 'PROTEIN SYNTHESIS' named entity 'INFLAMMATORY MARKERS' named entity 'CAUSE' named entity 'DEMONSTRATED' named entity 'STRAINS' named entity 'LEVEL' named entity 'ENGAGED' named entity 'DISEASES' named entity 'PIGS' named entity 'INSIGHT' named entity 'ENROLLED' named entity 'DAY 7' named entity 'ALMOST' named entity 'INTERFERON ' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'MICROARRAY ANALYSIS' named entity '7335' named entity 'GREATER' named entity 'EAST' named entity '1.5' named entity 'PATHOGENICITY' named entity 'DIFFERENT' named entity 'WORLDWIDE' named entity 'BOR' named entity 'FOLD CHANGE' named entity 'INVOLVED' named entity 'STIMULATED' named entity 'PATHWAYS' named entity 'IMMUNE DYSREGULATION' named entity 'CONTROL GROUP' named entity 'ACUTE PHASE RESPONSE' named entity 'ILI' named entity 'AGRANULOCYTE' named entity 'REPRODUCTIVE FAILURE' named entity 'GROUPS' named entity 'EXPRESSION PROFILE'

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