About: Statins: Could an old friend help the fight against COVID‐19?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Statins: Could an old friend help the fight against COVID‐19?
Creator	Ortiz, Alberto Egido, Jesus Es, Mruizo@fjd Marchant, Vanessa Marquez-Exposito, Laura Ramos, Adrian Rayego-Mateos, Sandra Rodrigues-Diez, Raul Ruiz-Ortega, Marta Santamaria, Lucía Santos Sanchez, Laura Tejera-Muñoz, Antonio
Source	Medline; PMC
abstract	COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has overwhelmed Healthcare Systems requiring the rapid development of treatments, at least, to reduce COVID‐19 severity. Drug repurposing offers a fast track. Here, we discuss the potential beneficial effects of statins in COVID‐19 patients based on evidence that they may target virus receptors, replication, degradation and downstream responses in infected cells, addressing both basic research and epidemiological information. Briefly, statins could act modulating virus entry, acting on the SARS‐CoV‐2 receptors, ACE2 and CD147, and/or lipid rafts engagement. Statins, by inducing autophagy activation, could regulate virus replication or degradation, exerting protective effects. The well‐known anti‐inflammatory properties of statins, by blocking several molecular mechanisms, including NF‐κB and NLRP3 inflammasome, could limit the “cytokine storm” in severe COVID‐19 patients which is linked to fatal outcome. Finally, statin moderation of coagulation response activation may also contribute to improve COVID‐19 outcomes.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1111/bph.15166
bibo:pmid	32562276
has license	no-cc
sha1sum (hex)	708cab91d4e0785166ae77ee845a12a13cb8ed84
schema:url	https://doi.org/10.1111/bph.15166
resource representing a document's title	Statins: Could an old friend help the fight against COVID‐19?
has PubMed Central identifier	PMC7323198
has PubMed identifier	32562276
schema:publication	Br J Pharmacol
resource representing a document's body	covid:708cab91d4e0785166ae77ee845a12a13cb8ed84#body_text
is schema:about of	named entity 'KNOWN' named entity 'ACTIVATION' named entity 'POTENTIAL' named entity 'BLOCKING' named entity 'DEVELOPMENT' named entity 'INDUCING' named entity 'BAB' named entity 'FAST' named entity 'coagulation' named entity 'lipid rafts' named entity 'NLRP3' named entity 'CD147' named entity 'SARS-CoV-2' named entity 'statins' named entity 'Nuclear factor' named entity 'TLR' named entity 'Rho-kinase' named entity 'phorbol' named entity 'Middle-East' named entity 'Renin' named entity 'Hepatitis B virus' named entity 'Carcinoembryonic antigen' named entity 'RLR' named entity 'Mammalian target of rapamycin' named entity 'Murine' named entity 'ischemic' named entity 'Hazard ratio' named entity 'Light chain' named entity 'Interferon regulatory factors' named entity 'RAS' named entity 'coenzyme' named entity 'methyl' named entity 'mTOR' named entity 'kinase' named entity 'Signal transducer and activator of transcription' named entity 'Disseminated intravascular coagulation' named entity 'protein' named entity 'DIC' named entity 'PI3K' named entity 'Angiotensin converting enzyme inhibitor' named entity 'HMG-CoA' named entity 'ACEi' named entity 'PAMPs' named entity 'RIG-I' named entity 'HCV' named entity 'Phosphatidylinositol 3-kinase' named entity 'virus' named entity 'virus' named entity 'host cells' named entity 'inflammasome' named entity 'fibrosis' named entity 'NLRP3' named entity 'SARS-CoV-1' named entity 'Intensive Care Unit' named entity 'Macroautophagy' named entity 'Ding Wei' named entity 'IUPHAR' named entity 'autophagy' named entity 'experimental studies' named entity 'RAS' named entity 'pneumonia' named entity 'autophagy' named entity 'homologue' named entity 'inflammasome' named entity 'atherosclerosis' named entity 'IL-1β' named entity 'statin' named entity 'CD147' named entity 'inflammasome' named entity 'COVID'

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