About: Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo

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About: Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo
Creator	He, Kongwang Wen, Libin Liu, Chuanmin Xiao, Qi
source	Medline; PMC
abstract	BACKGROUND: Nitric oxide (NO), an important signaling molecule with biological functions, has antimicrobial activity against a variety of pathogens including viruses. To our knowledge, little information is available about the regulatory effect of NO on porcine circovirus type 2 (PCV2) infection. This study was conducted to investigate the antiviral activity of NO generated from S-nitrosoglutathione (GSNO), during PCV2 infection of PK-15 cells and BALB/c mice. RESULTS: GSNO released considerable NO in the culture medium of PK-15 cells, and NO was scavenged by its scavenger hemoglobin (Hb) in a dose-dependent manner. NO strongly inhibited PCV2 replication in PK-15 cells, and the antiviral effect was reversed by Hb. An in vivo assay indicated that GSNO treatment reduced the progression of PCV2 infection in mice, evident as reductions in the percentages of PCV2-positive sera and tissue samples and in the viral DNA copies in serum samples. GSNO also improved the growth performance and immune organs (spleens and thymuses) of the PCV2-infected mice to some degree. CONCLUSIONS: Our data demonstrate that the NO-generating compound GSNO suppresses PCV2 infection in PK-15 cells and BALB/c mice, indicating that NO and its donor, GSNO, have potential value as antiviral drugs against PCV2 infection.
has issue date	2017-02-21(xsd:dateTime)
bibo:doi	10.1186/s12917-017-0976-9
bibo:pmid	28222773
has license	cc-by
sha1sum (hex)	70748788b2a175a08f02878c528efbd024a45064
schema:url	https://doi.org/10.1186/s12917-017-0976-9
resource representing a document's title	Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo
has PubMed Central identifier	PMC5320642
has PubMed identifier	28222773
schema:publication	BMC Vet Res
resource representing a document's body	covid:70748788b2a175a08f02878c528efbd024a45064#body_text
is schema:about of	named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'generated' named entity 'biological functions' named entity 'antimicrobial' named entity 'compound' named entity 'IN VITRO' covid:arg/70748788b2a175a08f02878c528efbd024a45064 named entity 'GENERATING' named entity 'ANTIMICROBIAL ACTIVITY' named entity 'CELLS' named entity 'COMPOUND' named entity 'AVAILABLE' named entity 'VARIETY' named entity 'ANTIVIRAL ACTIVITY' named entity 'BACKGROUND' named entity 'OUR' named entity 'INFECTION' named entity 'LITTLE' named entity 'INFECTION' named entity 'INFORMATION' named entity 'SIGNALING MOLECULE' named entity 'PATHOGENS' named entity 'BALB' named entity 'BIOLOGICAL FUNCTIONS' named entity 'MICE' named entity 'PORCINE CIRCOVIRUS TYPE 2' named entity 'TO INVESTIGATE' named entity 'INCLUDING' named entity 'NITRIC OXIDE' named entity 'IN VIVO' named entity 'KNOWLEDGE' named entity 'EFFECT' named entity 'SUPPRESSES' named entity 'REGULATORY' named entity 'ABOUT' named entity 'NITRIC OXIDE' named entity 'GSNO' named entity 'S-NITROSOGLUTATHIONE' named entity 'GENERATED' named entity 'VIRUSES' named entity 'STUDY' named entity 'IMPORTANT' named entity 'conducted' named entity 'viruses' named entity 'porcine circovirus' named entity 'Nitric oxide' named entity 'porcine circovirus' named entity 'viruses' named entity 'PCV2' named entity 'antimicrobial activity' named entity 'Nitric oxide' named entity 'infection' named entity 'S-nitrosoglutathione' named entity 'Nitric oxide' named entity 'apoptosis' named entity 'antimicrobial' named entity 'PCR' named entity 'spleens' named entity 'Jiangsu' named entity 'microliter' named entity 'PCV2' named entity 'PVC2' named entity 'porcine' named entity 'mice' named entity '37°C' named entity 'TaqMan' named entity 'PCV2' named entity 'Beijing' named entity '0.01' named entity 'scavenger' named entity 'mice' named entity 'infection' named entity 'pathological processes' named entity 'antiviral activity' named entity 'PCV2' named entity 'antiviral' named entity 'PCV2' named entity 'cell culture'

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