About: Retrospective Observational Study of Brain Magnetic Resonance Imaging Findings in Patients with Acute SARS-CoV-2 Infection and Neurological Manifestations

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About: Retrospective Observational Study of Brain Magnetic Resonance Imaging Findings in Patients with Acute SARS-CoV-2 Infection and Neurological Manifestations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Retrospective Observational Study of Brain Magnetic Resonance Imaging Findings in Patients with Acute SARS-CoV-2 Infection and Neurological Manifestations
Creator	Demeret, Sophie Seilhean, Danielle Demoule, Alexandre Paris, France Burrel, Sonia Degos, Vincent Galanaud, Damien Morawiec, Elise Pyatigorskaya, Nadya Raux, Mathieu Shor, Natalia Similowski, Thomas Weiss, Nicolas Belkacem, Samia Chougar, Lydia Corvol, Jean-Christophe David Boutolleau, ; Delorme, Cécile Dormont, ; Gerber, Sophie Leclercq, Delphine Lehéricy, Stéphane Mathon, Bertrand Rosso, Charlotte Rufat, Pierre Stroër, Sebastian Stéphanie Trunet, ;
Source	Medline; PMC
abstract	BACKGROUND: This study provides a detailed imaging assessment in a large series of COVID-19 patients with neurological manifestations. PURPOSE: To review the MRI findings associated with acute neurological manifestations in COVID-19 patients. METHODS: This was a cross-sectional study conducted between March 23 and May 7, 2020 at the Pitié-Salpêtrière University Hospital, a reference center for COVID-19 in the Paris area. Inclusion criteria were: adult patients diagnosed with SARS-CoV-2 infection, presenting with acute neurological manifestations and referred for a brain MRI examination. Patients were excluded if they had a previous history of neurological disease. The characteristics and the frequency of different MRI features were investigated. The findings were analyzed separately in patients in intensive care units (ICU) and other departments (non-ICU). RESULTS: During the inclusion period, 1176 consecutive patients were hospitalized for suspected COVID-19. Out of 308 patients with acute neurological symptoms, 73 patients met the inclusion criteria (23.7%) and were included: 35 ICU patients (47.9%) and 38 non-ICU patients (52.1%). The mean age was 58.5 ± 15.6 years, with a male predominance (65.8% vs. 34.2%). Forty-three patients presented pathological MRI findings 2-4 weeks after symptom onset (58.9%), including 17 with acute ischemic infarct (23.3%), 1 with a deep venous thrombosis (1.4%), 8 with multiple microhemorrhages (11.3%), 22 with perfusion abnormalities (47.7%), 3 with restricted diffusion foci within the corpus callosum consistent with cytotoxic lesions of the corpus callosum (CLOCC, 4.1%). Multifocal white matter enhancing lesions were seen in 4 ICU patients (5%). Basal ganglia abnormalities were seen in 4 other patients (5%). The cerebrospinal fluid (CSF) analysis was negative for SARS-CoV-2 in all tested patients (n=39). CONCLUSION: In addition to cerebrovascular lesions, perfusion abnormalities, CLOCC and ICU-related complications, we identified two patterns including white matter enhancing lesions and basal ganglia abnormalities that could be related to SARS-CoV-2 infection.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1148/radiol.2020202422
bibo:pmid	32677875
has license	no-cc
sha1sum (hex)	70269c710d990fffcc0852cfad8a5c82b5f04ca2
schema:url	https://doi.org/10.1148/radiol.2020202422
resource representing a document's title	Retrospective Observational Study of Brain Magnetic Resonance Imaging Findings in Patients with Acute SARS-CoV-2 Infection and Neurological Manifestations
has PubMed Central identifier	PMC7370354
has PubMed identifier	32677875
schema:publication	Radiology
resource representing a document's body	covid:70269c710d990fffcc0852cfad8a5c82b5f04ca2#body_text
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