About: Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil

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About: Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil
Creator	Huh, Warner Damke, Edilson Pelloso, Sandra Scarinci, Isabel Suehiro, Tamy Argemiro, Ricardo Da Silva, Sela De Andrade, Marcela Ferreira Damke, Zago Franco, Fonseca Lopes Consolaro, Marcia Marconi, Gabrielle Ramos, Azevedo Ramos, Vânia Rodrigues, Paloma Silva, Pereira
source	PMC
abstract	BACKGROUND: Despite the demonstrated role of human Papillomavirus (HPV) in the etiology of cervical cancer and the strong evidence suggesting the importance of HPV in the development of oropharyngeal cancer, several aspects of the interrelationship between HPV infection in both body sites remain unknown, specifically in female human immunodeficiency virus (HIV)-positive (HIV+) patients. We aimed to assess the prevalence, distribution, and concordance of cervical and oral HPV in HIV+ women and matched HIV-negative (HIV-) controls in Brazil. MATERIAL AND METHODS: Cervical and endocervical samples for cytological screening and HPV detection and oral samples were collected from 115 HIV+ women using highly active antiretroviral therapy (HAART) and 139 HIV-matched controls (HIV-) in Maringá City, Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding HIV infection were obtained from the patients’ medical records. HPV detection and typing were performed using the Kit Multiplex XGEN Multi HPV Chip HS12. RESULTS: HIV infection was well controlled in this cohort, but women who exhibited detectable HIV loads were significantly associated with HPV-positive status overall (P = 0.03) and in cervical mucosa (P = 0.01). HIV+ women had significantly more abnormal cytological findings (P = 0.04) than HIV- women. Of the 115 HIV+ women, 48.7% were positive for cervical and/or oral HPV DNA; of the 139 HIV- women, 41% were positive for cervical and/or oral HPV (P = 0.25). Both HIV+ and HIV- women had a statistically higher prevalence of cervical HPV infection than oral infection. The concurrent HPV infection in two anatomical sites was similar in HIV+ and HIV- women; however, HPV type concordance was not observed. HPV type distribution was different between the anatomical sites in both groups, and HIV+ women presented less common types, mainly in oral mucosa. CONCLUSION: Our data support the importance of testing HPV infection in HIV+ women, even when the HIV infection is well controlled. Prospective studies are required to better understand the natural history of HPV infection in both anatomical sites, specifically in HIV+ women.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1186/s13027-020-00301-y
bibo:pmid	32426032
has license	cc-by
sha1sum (hex)	6ffb01b69ab958c75307dd17e6589f593b89bece
schema:url	https://doi.org/10.1186/s13027-020-00301-y
resource representing a document's title	Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil
has PubMed Central identifier	PMC7216672
has PubMed identifier	32426032
schema:publication	Infect Agent Cancer
resource representing a document's body	covid:6ffb01b69ab958c75307dd17e6589f593b89bece#body_text
is schema:about of	named entity 'etiology' named entity 'remain' named entity 'patients' named entity 'human Papillomavirus (HPV)' named entity 'matched' named entity 'ETIOLOGY' named entity 'BACKGROUND' named entity 'BRAZIL' named entity 'HIV' named entity 'STRONG' named entity 'CONCORDANCE' named entity 'positive' named entity 'Despite' named entity 'cervical cancer' named entity 'prevalence' named entity 'etiology' named entity 'HIV' named entity 'HIV-negative' named entity 'oropharyngeal cancer' named entity 'HPV' named entity 'human immunodeficiency virus' named entity 'HIV' named entity 'infectious agents' named entity 'State University of Maringá' named entity 'HPV infection' named entity 'HPV' named entity 'HIV' named entity 'prognosis' named entity 'HIV' named entity 'confidence intervals' named entity 'HIV' named entity 'HIV' named entity 'HIV+ women' named entity 'infection' named entity 'cytological' named entity 'Statistical analyses' named entity 'oral mucosa' named entity 'HPV' named entity 'HIV' named entity 'HIV+ women' named entity 'HIV' named entity 'HIV+ women' named entity 'etiology' named entity 'HPV' named entity 'HPV' named entity '21.4%' named entity 'HPV' named entity 'clinical characteristics' named entity 'HPV' named entity '95% confidence interval' named entity 'vaccination' named entity 'HIV+' named entity 'HPV' named entity 'risk factors' named entity 'cytological' named entity 'HIV-negative' named entity 'HIV+' named entity 'HIV+' named entity 'HSIL' named entity 'HIV' named entity 'HPV infections' named entity 'antiretroviral therapy' named entity 'HIV+ women' named entity 'HIV+' named entity 'precancerous lesions' named entity 'confidence interval'

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