About: Human aminopeptidase N is a receptor for human coronavirus 229E

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About: Human aminopeptidase N is a receptor for human coronavirus 229E Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human aminopeptidase N is a receptor for human coronavirus 229E
Creator	Holmes, Kathryn Ashmunt:/:, Richard Cardeillchio, Christine Lookt, A Shapirot, Linda Wlliams, Richard Yeager, Curtis
Source	Medline; PMC
abstract	HUMAN coronaviruses (HCV) in two serogroups represented by HCV-229E and HCV-OC43 are an important cause of upper respiratory tract infections(1). Here we report that human aminopeptidase N, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells(2–5), is a receptor for human coronavirus strain HCV-229E, but not for HCV-OC43. A monoclonal antibody, RBS, blocked HCV-229E virus infection of human lung fibroblasts, immunoprecipitated aminopeptidase N and inhibited its enzymatic activity. HCV-229E-resistant murine fibroblasts became susceptible after transfection with complementary DNA encoding human aminopeptidase N. By contrast, infection of human cells with HCV-OC43 was not inhibited by antibody RBS and expression of aminopeptidase N did not enhance HCV-OC43 replication in mouse cells. A mutant aminopeptidase lacking the catalytic site of the enzyme did not bind HCV-229E or RBS and did not render murine cells susceptible to HCV-229E infection, suggesting that the virus-binding site may lie at or near the active site of the human aminopeptidase molecule.
has issue date	1992-01-01(xsd:dateTime)
bibo:doi	10.1038/357420a0
bibo:pmid	1350662
has license	no-cc
sha1sum (hex)	6fcf7a9b95a53e1ab89b02f3bf6336457c18dca7
schema:url	https://doi.org/10.1038/357420a0
resource representing a document's title	Human aminopeptidase N is a receptor for human coronavirus 229E
has PubMed Central identifier	PMC7095410
has PubMed identifier	1350662
schema:publication	Nature
resource representing a document's body	covid:6fcf7a9b95a53e1ab89b02f3bf6336457c18dca7#body_text
is schema:about of	named entity 'HCV' named entity 'serogroups' named entity 'immunoprecipitated' named entity 'blocked' named entity 'complementary DNA' named entity 'receptor' named entity 'NATURE' covid:arg/6fcf7a9b95a53e1ab89b02f3bf6336457c18dca7 named entity 'monoclonal antibody' named entity 'aminopeptidase N' named entity 'HUMAN' named entity 'virus' named entity 'human cells' named entity 'mutant' named entity 'coronavirus' named entity 'RBS' named entity 'OC43' named entity '229E' named entity 'monoclonal antibody' named entity 'aminopeptidase' named entity 'antibody' named entity 'cell-surface' named entity '229E' named entity 'enzymatic activity' named entity 'infection' named entity 'aminopeptidase' named entity 'infection' named entity 'fibroblasts' named entity 'HCV' named entity 'HCV' named entity 'aminopeptidase' named entity 'HCV' named entity 'epithelial' named entity '229E' named entity 'receptor' named entity '37°C' named entity 'serogroup' named entity 'receptor' named entity '229E' named entity 'catalytic site' named entity 'zinc' named entity 'acetone' named entity 'metalloprotease' named entity 'antibodies' named entity 'HCV' named entity 'mammals' named entity 'PBS' named entity 'CD13' named entity 'HCV' named entity 'substrate' named entity 'transfected' named entity 'isotonic' named entity 'polypeptide' named entity 'retroviral vector' named entity 'coronaviruses' named entity 'enzymatic activity' named entity 'HCV' named entity 'human cell lines' named entity 'CD13' named entity 'phenanthroline' named entity 'flow cytometry' named entity 'infection' named entity 'mice' named entity '3T3 cells' named entity '229E' named entity 'virus' named entity 'NIH3T3' named entity '229E' named entity 'aminopeptidase' named entity 'antibodies' named entity 'receptor' named entity 'infection' named entity 'receptor' named entity 'binding sites' named entity 'human chromosome 15'

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