About: IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine

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About: IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle
Creator	Indalao, I Kido, • Sawabuchi, • Takahashi, •
Source	Medline; PMC
abstract	Severe influenza is characterized by a cytokine storm, and the influenza virus–cytokine–trypsin cycle is one of the important mechanisms of viral multiplication and multiple organ failure. The aim of this study was to define the key cytokine(s) responsible for trypsin upregulation. Mice were infected with influenza virus strain A/Puerto Rico/8/34 (H1N1) or treated individually or with a combination of interleukin-1β, interleukin-6, and tumor necrosis factor α. The levels of these cytokines and trypsin in the lungs were monitored. The neutralizing effects of anti-IL-1β antibodies on cytokine and trypsin expression in human A549 cells and lung inflammation in the infected mice were examined. Infection induced interleukin-1β, interleukin-6, tumor necrosis factor α, and ectopic trypsin in mouse lungs in a dose- and time-dependent manner. Intraperitoneal administration of interleukin-1β combined with other cytokines tended to upregulate trypsin and cytokine expression in the lungs, but the combination without interleukin-1β did not induce trypsin. In contrast, incubation of A549 cells with interleukin-1β alone induced both cytokines and trypsin, and anti-interleukin-1β antibody treatment abrogated these effects. Administration of the antibody in the infected mice reduced lung inflammation area. These findings suggest that IL-1β plays a key role in trypsin upregulation and has a pathological role in multiple organ failure.
has issue date	2016-10-06(xsd:dateTime)
bibo:doi	10.1007/s00705-016-3093-3
bibo:pmid	27714503
has license	cc-by
sha1sum (hex)	6fa9d1fe1938a48f36f837cec479925de3a69b64
schema:url	https://doi.org/10.1007/s00705-016-3093-3
resource representing a document's title	IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle
has PubMed Central identifier	PMC5225228
has PubMed identifier	27714503
schema:publication	Arch Virol
resource representing a document's body	covid:6fa9d1fe1938a48f36f837cec479925de3a69b64#body_text
is schema:about of	named entity 'UPREGULATION' named entity 'trypsin' named entity 'antibody' named entity 'neutralizing' named entity 'combination' named entity 'tumor necrosis factor' named entity 'reduced' named entity 'key' named entity 'key' named entity 'viral' named entity 'cytokines' named entity 'infected' named entity 'trypsin' named entity 'mechanisms' named entity 'IS A' named entity 'CYCLE' named entity 'THESE' named entity 'FACTOR A' named entity 'ECTOPIC' named entity 'INFECTION INDUCED' named entity 'HUMAN' named entity 'CYCLE' named entity 'RICO' named entity 'MONITORED' named entity 'AREA' named entity 'BUT' named entity 'DEPENDENT' named entity 'SEVERE' named entity '28S' named entity 'ONE OF' named entity 'CYTOKINE' named entity 'TRYPSIN' named entity 'KEY' named entity 'CHARACTERIZED' named entity 'REDUCED' named entity 'ANTIBODY' named entity 'INFLUENZA' named entity '2F8' named entity 'MICE' named entity 'IL-1B' named entity 'LUNGS' named entity 'LEVELS' named entity 'EXPRESSION' named entity 'AIM' named entity 'A549 CELLS' named entity 'RESPONSIBLE' named entity 'IMPORTANT' named entity 'ANTIBODY TREATMENT' named entity 'CONTRAST' named entity 'PLAYS' named entity 'MECHANISMS' named entity 'INFECTED' named entity 'EXAMINED' named entity 'INDUCED' named entity 'ADMINISTRATION' named entity 'ANTIBODIES' named entity 'INTERLEUKIN' named entity 'TREATED' named entity 'UPREGULATION' named entity 'VIRAL' named entity 'INFLUENZA VIRUS' named entity 'TIME' named entity 'MULTIPLICATION' named entity 'COMBINATION' named entity 'IL-1B' named entity 'INFLUENZA VIRUS' named entity 'THE LUNGS' named entity 'LUNG INFLAMMATION' named entity 'INTERLEUKIN-6' named entity 'DOSE' named entity 'CYTOKINE EXPRESSION' named entity 'STRAIN' named entity 'FINDINGS' named entity 'COMBINED' named entity 'INDUCE' named entity 'PATHOLOGICAL ROLE' named entity 'DID' named entity 'STUDY'

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