About: Innate Type 2 Responses to Respiratory Syncytial Virus Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Innate Type 2 Responses to Respiratory Syncytial Virus Infection
Creator	Stokes Peebles, R Norlander, Allison
source	PMC
abstract	Respiratory syncytial virus (RSV) is a common and contagious virus that results in acute respiratory tract infections in infants. In many cases, the symptoms of RSV remain mild, however, a subset of individuals develop severe RSV-associated bronchiolitis. As such, RSV is the chief cause of infant hospitalization within the United States. Typically, the immune response to RSV is a type 1 response that involves both the innate and adaptive immune systems. However, type 2 cytokines may also be produced as a result of infection of RSV and there is increasing evidence that children who develop severe RSV-associated bronchiolitis are at a greater risk of developing asthma later in life. This review summarizes the contribution of a newly described cell type, group 2 innate lymphoid cells (ILC2), and epithelial-derived alarmin proteins that activate ILC2, including IL-33, IL-25, thymic stromal lymphopoietin (TSLP), and high mobility group box 1 (HMGB1). ILC2 activation leads to the production of type 2 cytokines and the induction of a type 2 response during RSV infection. Intervening in this innate type 2 inflammatory pathway may have therapeutic implications for severe RSV-induced disease.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.3390/v12050521
bibo:pmid	32397226
has license	cc-by
sha1sum (hex)	6fa9233f054f4bbb31972e05c1478b0ec83ccc16
schema:url	https://doi.org/10.3390/v12050521
resource representing a document's title	Innate Type 2 Responses to Respiratory Syncytial Virus Infection
has PubMed Central identifier	PMC7290766
has PubMed identifier	32397226
schema:publication	Viruses
resource representing a document's body	covid:6fa9233f054f4bbb31972e05c1478b0ec83ccc16#body_text
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