About: Animal Models and Vaccines for SARS-CoV Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Animal Models and Vaccines for SARS-CoV Infection
Creator	Baric, Ralph Subbarao, Kanta Vogel, Leatrice Roberts, Anjeanette Guarner, Jeannette Sheahan, Timothy Zaki, Sherif Lamirande, Elaine Paddock, Christopher Jackson, Jadon
source	Elsevier; Medline; PMC
abstract	We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV.
has issue date	2008-04-01(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2007.03.025
bibo:pmid	17499378
has license	bronze-oa
sha1sum (hex)	6f9add1bf870eee4191404a25236d2575315e108
schema:url	https://doi.org/10.1016/j.virusres.2007.03.025
resource representing a document's title	Animal Models and Vaccines for SARS-CoV Infection
has PubMed Central identifier	PMC2323511
has PubMed identifier	17499378
schema:publication	Virus Research
resource representing a document's body	covid:6f9add1bf870eee4191404a25236d2575315e108#body_text
is schema:about of	named entity 'Syrian hamsters' named entity 'animals' named entity 'provide' named entity 'summarize' named entity 'VACCINES' named entity 'CHALLENGE' named entity 'ADDITIONAL' named entity 'PROTECTING' named entity 'GOLDEN' named entity 'EFFICACY' named entity 'INFECTIONS' named entity 'DEGREES' named entity 'MICE' named entity 'SYRIAN HAMSTERS' named entity 'CHANGES' named entity 'HETEROLOGOUS' named entity 'INFECTION' named entity 'ANIMAL MODELS ' named entity 'SUPPORT' named entity 'AGED' named entity 'LUNGS' named entity 'DISCUSS' named entity 'REPLICATION' named entity 'IN VIVO' named entity 'INFECTED' named entity 'STRAINS' named entity 'IN VITRO' named entity 'REPORTED' named entity 'ADDRESSING' named entity 'PROVIDE' named entity 'REPORT' named entity 'VARYING' named entity 'VIRAL REPLICATION' named entity 'DATA' named entity 'FOLLOWING' named entity '129S6' named entity 'PREVIOUSLY' named entity 'SARS-COV INFECTION' named entity 'LEVELS' named entity 'CROSS' named entity 'VACCINE' named entity 'ASSOCIATED' named entity 'ANTIBODY TITERS' named entity 'FINDINGS' named entity 'SIGNS OF ILLNESS' named entity 'ENHANCEMENT' named entity 'VARIETY' named entity 'ANIMALS' named entity 'HISTOPATHOLOGICAL' named entity 'ANIMAL MODELS ' named entity 'SARS-COV' named entity 'NEW' named entity 'VARIOUS' named entity 'VACCINATED' named entity 'THESE' named entity 'APPROACHES' named entity 'PATHOLOGY' named entity 'NEUTRALIZING ANTIBODY' named entity 'AVAILABLE' named entity 'DISEASE' named entity 'POTENTIAL' named entity 'C57BL/6' named entity 'vaccinated' named entity 'strains' named entity 'viral replication' named entity 'strains' named entity 'golden' named entity 'potential' named entity 'viral replication' named entity 'levels' named entity 'SARS-CoV' named entity 'Animal'

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