About: Synthetic viruses: a new opportunity to understand and prevent viral disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthetic viruses: a new opportunity to understand and prevent viral disease
Creator	Mueller, Steffen Wimmer, Eckard Taubenberger, Jeffery Tumpey, Terrence
Source	Medline; PMC
abstract	Rapid progress in DNA synthesis and sequencing is spearheading the deliberate, large-scale genetic alteration of organisms. These new advances in DNA manipulation have been extended to the level of whole-genome synthesis, as evident from the synthesis of poliovirus, from the resurrection of the extinct 1918 strain of influenza virus and of human endogenous retroviruses and from the restructuring of the phage T7 genome. The largest DNA synthesized so far is the 582,970 base pair genome of Mycoplasma genitalium, although, as yet, this synthetic DNA has not been ‘booted’ to life. As genome synthesis is independent of a natural template, it allows modification of the structure and function of a virus’s genetic information to an extent that was hitherto impossible. The common goal of this new strategy is to further our understanding of an organism’s properties, particularly its pathogenic armory if it causes disease in humans, and to make use of this new information to protect from, or treat, human viral disease. Although only a few applications of virus synthesis have been described as yet, key recent findings have been the resurrection of the 1918 influenza virus and the generation of codon- and codon pair–deoptimized polioviruses.
has issue date	2009-12-01(xsd:dateTime)
bibo:doi	10.1038/nbt.1593
bibo:pmid	20010599
has license	green-oa
sha1sum (hex)	6f8f494baf1a8050a35dd64ad5911133fcfb722d
schema:url	https://doi.org/10.1038/nbt.1593
resource representing a document's title	Synthetic viruses: a new opportunity to understand and prevent viral disease
has PubMed Central identifier	PMC2819212
has PubMed identifier	20010599
schema:publication	Nature Biotechnology
resource representing a document's body	covid:6f8f494baf1a8050a35dd64ad5911133fcfb722d#body_text
is schema:about of	named entity 'PREVENT' named entity 'Although' named entity 'genome' named entity 'human' named entity 'SYNTHETIC' named entity 'NEW' named entity 'ORGANISMS' named entity 'PAIR' named entity 'NEW' named entity 'UNDERSTAND' named entity 'COMMON' named entity 'MAKE' named entity 'SYNTHESIS' named entity 'TEMPLATE' named entity 'GENETIC ALTERATION' named entity 'SEQUENCING' named entity 'CODON' named entity 'FAR' named entity 'POLIOVIRUSES' named entity 'OUR' named entity 'ITS' named entity 'HUMAN' named entity 'RECENT' named entity 'DNA SYNTHESIS' named entity 'FINDINGS' named entity 'UNDERSTANDING' named entity 'ALLOWS' named entity 'APPLICATIONS' named entity 'TREAT' named entity 'HUMAN ENDOGENOUS RETROVIRUSES' named entity 'GOAL' named entity 'POLIOVIRUS' named entity 'NEW INFORMATION' named entity 'PHAGE T7' named entity 'MODIFICATION' named entity 'VIRAL DISEASE' named entity 'I E' named entity 'GENETIC INFORMATION' named entity 'VIRAL DISEASE' named entity 'INFLUENZA VIRUS' named entity '1918' named entity 'LIFE' named entity 'OPPORTUNITY' named entity 'SYNTHETIC DNA' named entity 'EXTENDED' named entity '27S' named entity 'FUNCTION' named entity 'CAUSES DISEASE IN HUMANS' named entity 'GENOME' named entity 'ORGANISM' named entity 'LARGEST' named entity 'PROPERTIES' named entity 'STRATEGY' named entity 'MYCOPLASMA GENITALIUM' named entity 'VIRUSES' named entity 'USE OF' named entity 'PROGRESS' named entity 'DESCRIBED' named entity 'DNA' named entity 'LEVEL' named entity 'VIRUS' named entity 'NATURAL' named entity 'STRAIN' named entity 'EXTENT' named entity 'STRUCTURE' named entity 'RAPID' named entity 'SCALE' named entity 'LARGE' named entity 'BASE PAIR' named entity 'KEY' named entity 'GENERATION' named entity 'PATHOGENIC' named entity 'EXTINCT' named entity 'MANIPULATION' named entity 'IMPOSSIBLE' named entity 'HAVE' named entity 'THESE' named entity 'INDEPENDENT OF'

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