About: Activity based protein profiling to detect serine hydrolase alterations in virus infected cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activity based protein profiling to detect serine hydrolase alterations in virus infected cells
Creator	Coombs, Kevin Shahiduzzaman, Md Shuda, Masa Speijer, Dave
Source	PMC
abstract	Activity-based protein profiling (ABPP) is a newly emerging technique that uses active site-directed probes to monitor the functional status of enzymes. Serine hydrolases are one of the largest families of enzymes in mammals. More than 200 serine hydrolases have been identified, but little is known about their specific roles. Serine hydrolases are involved in a variety of physiological functions, including digestion, immune response, blood coagulation, and reproduction. ABPP has been used recently to investigate host–virus interactions and to understand the molecular pathogenesis of virus infections. Monitoring the altered serine hydrolases during viral infection gives insight into the catalytic activity of these enzymes that will help to identify novel targets for diagnostic and therapeutic application. This review presents the usefulness of ABPP in detecting and analyzing functional annotation of host cell serine hydrolases as a result of host–virus interaction.
has issue date	2012-08-22(xsd:dateTime)
bibo:doi	10.3389/fmicb.2012.00308
bibo:pmid	23024641
has license	cc-by
sha1sum (hex)	6f3c5be389b060803e0eaa4727b6180637168dad
schema:url	https://doi.org/10.3389/fmicb.2012.00308
resource representing a document's title	Activity based protein profiling to detect serine hydrolase alterations in virus infected cells
has PubMed Central identifier	PMC3441198
has PubMed identifier	23024641
schema:publication	Front Microbiol
resource representing a document's body	covid:6f3c5be389b060803e0eaa4727b6180637168dad#body_text
is schema:about of	named entity 'ARTICLE' named entity 'Serine' named entity 'immune response' named entity 'monitor' named entity 'ARTICLE' named entity 'PROTEIN PROFILING' named entity 'PHYSIOLOGICAL' named entity 'PROTEIN PROFILING' named entity 'INFECTIONS' named entity 'VIRUS' named entity 'HYDROLASES' named entity 'IS A' named entity 'ENZYMES' named entity 'KNOWN' named entity 'DIAGNOSTIC' named entity 'UNDERSTAND' named entity 'MONITOR' named entity 'INVOLVED' named entity 'SPECIFIC' named entity 'PATHOGENESIS' named entity 'INTERACTIONS' named entity 'ROLES' named entity 'NEWLY' named entity 'REPRODUCTION' named entity 'IDENTIFIED' named entity 'BUT' named entity 'INCLUDING' named entity 'HOST' named entity 'THERAPEUTIC' named entity 'APPLICATION' named entity 'HELP' named entity 'VARIETY' named entity 'USEFULNESS' named entity 'DIGESTION' named entity 'ACTIVE' named entity 'RECENTLY' named entity 'MONITORING' named entity 'USES' named entity 'LARGEST' named entity 'REVIEW' named entity 'HOST-VIRUS INTERACTION' named entity 'MAMMALS' named entity 'ABPP' named entity 'LITTLE' named entity 'BLOOD COAGULATION' named entity 'FUNCTIONAL STATUS' named entity 'FUNCTIONS' named entity 'VIRAL INFECTION' named entity 'HAVE' named entity 'ACTIVITY' named entity 'MOLECULAR' named entity 'SERINE HYDROLASE' named entity 'ALTERATIONS' named entity 'TO DETECT' named entity 'INSIGHT' named entity 'ACTIVITY' named entity 'REVIEW' named entity 'VIRUS' named entity 'MORE THAN' named entity 'PROBES' named entity 'DETECTING' named entity 'ONE OF' named entity 'AS A RESULT OF' named entity 'TARGETS' named entity 'FAMILIES' named entity 'ANALYZING' named entity 'CATALYTIC ACTIVITY' named entity 'TO IDENTIFY' named entity 'FUNCTIONAL' named entity 'IMMUNE RESPONSE' named entity '200' named entity 'SERINE' named entity 'HOST CELL' named entity 'CELLS' named entity 'MINI' named entity 'INFECTED' named entity 'BASED' named entity 'TECHNIQUE'

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