About: Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study
Creator	Aylward, Ryan Baker, Debbie Ensor, Jason Freercks, Robert Pazi, Sisa Van Der Merwe, Elizabeth Van Niekerk, Minette
Source	PMC
abstract	BACKGROUND: There is a marked paucity of data concerning AKI in Sub-Saharan Africa, where there is a substantial burden of trauma and HIV. METHODS: Prospective data was collected on all patients admitted to a multi-disciplinary ICU in South Africa during 2017. Development of AKI (before or during ICU admission) was recorded and renal recovery 90 days after ICU discharge was determined. RESULTS: Of 849 admissions, the mean age was 42.5 years and mean SAPS 3 score was 48.1. Comorbidities included hypertension (30.5%), HIV (32.6%), diabetes (13.3%), CKD (7.8%) and active tuberculosis (6.2%). The most common reason for admission was trauma (26%). AKI developed in 497 (58.5%). Male gender, illness severity, length of stay, vasopressor drugs and sepsis were independently associated with AKI. AKI was associated with a higher in-hospital mortality rate of 31.8% vs 7.23% in those without AKI. Age, active tuberculosis, higher SAPS 3 score, mechanical ventilation, vasopressor support and sepsis were associated with an increased adjusted odds ratio for death. HIV was not independently associated with AKI or hospital mortality. CKD developed in 14 of 110 (12.7%) patients with stage 3 AKI; none were dialysis-dependent. CONCLUSIONS: In this large prospective multidisciplinary ICU cohort of younger patients, AKI was common, often associated with trauma in addition to traditional risk factors and was associated with good functional renal recovery at 90 days in most survivors. Although the HIV prevalence was high and associated with higher mortality, this was related to the severity of illness and not to HIV status per se.
has issue date	2019-12-10(xsd:dateTime)
bibo:doi	10.1186/s12882-019-1620-7
bibo:pmid	31822290
has license	cc-by
sha1sum (hex)	6f272071ba1d16200a998e407994e66be0f0d60d
schema:url	https://doi.org/10.1186/s12882-019-1620-7
resource representing a document's title	Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study
has PubMed Central identifier	PMC6902455
has PubMed identifier	31822290
schema:publication	BMC Nephrol
resource representing a document's body	covid:6f272071ba1d16200a998e407994e66be0f0d60d#body_text
is schema:about of	named entity 'higher' named entity 'functional' named entity 'Male' named entity 'cohort' named entity 'AKI' named entity 'independently' named entity 'hypertension' named entity 'sepsis' named entity '2017' named entity 'odds ratio' named entity 'traditional' named entity 'discharge' named entity 'illness' named entity 'vasopressor' named entity 'multi-disciplinary' named entity 'recovery' named entity 'marked' named entity 'mortality' named entity 'good' named entity 'HIV' named entity 'trauma' named entity 'AKI' named entity 'admission' named entity 'HIV' named entity 'common' named entity 'ICU' named entity 'renal' named entity 'independently' named entity 'higher' named entity 'critically ill' named entity 'mortality rate' named entity 'tuberculosis' named entity 'hypertension' named entity 'diabetes' named entity 'HIV' named entity 'Comorbidities' named entity 'HIV' named entity 'South Africa' named entity 'HIV' named entity 'critically ill' named entity 'prospective cohort study' named entity 'Demographic data' named entity 'AKI' named entity 'AKI' named entity 'long-term' named entity 'chi-squared' named entity 'South Africa' named entity 'AKI' named entity 'dialysis' named entity 'Walter Sisulu University' named entity 'ICU' named entity 'government-funded' named entity 'p-value' named entity 'biopsies' named entity 'comorbidity' named entity 'microliter' named entity 'sepsis' named entity 'AKI' named entity 'AKI' named entity 'HIV' named entity 'AKI' named entity 'AKI' named entity 'HIV' named entity 'urban setting' named entity 'renal function' named entity 'AKI' named entity 'AKI' named entity 'Democratic Republic of Congo' named entity 'hospital discharge' named entity 'AKI' named entity 'dialyzed' named entity 'epidemiology' named entity 'nephrologist' named entity 'tested for HIV' named entity 'South Africa'

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