About: H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

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About: H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice
Creator	García-Sastre, A Katz, J Tumpey, T Perrone, L Plowden, J
Source	PMC
abstract	Fatal human respiratory disease associated with the 1918 pandemic influenza virus and potentially pandemic H5N1 viruses is characterized by severe lung pathology, including pulmonary edema and extensive inflammatory infiltrate. Here, we quantified the cellular immune response to infection in the mouse lung by flow cytometry and demonstrate that mice infected with highly pathogenic (HP) H1N1 and H5N1 influenza viruses exhibit significantly high numbers of macrophages and neutrophils in the lungs compared to mice infected with low pathogenic (LP) viruses. Mice infected with the 1918 pandemic virus and a recent H5N1 human isolate show considerable similarities in overall lung cellularity, lung immune cell sub-population composition and cellular immune temporal dynamics. Interestingly, while these similarities were observed, the HP H5N1 virus consistently elicited significantly higher levels of pro-inflammatory cytokines in whole lungs and primary human macrophages, revealing a potentially critical difference in the pathogenesis of H5N1 infections. These results together show that infection with HP influenza viruses such as H5N1 and the 1918 pandemic virus leads to a rapid cell recruitment of macrophages and neutrophils into the lungs, suggesting that these cells play a role in acute lung inflammation associated with HP influenza virus infection. In addition, primary macrophages and dendritic cells were also susceptible to 1918 and H5N1 influenza virus infection in vitro and in infected mouse lung tissue.
has issue date	2008-08-01(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1000115
bibo:pmid	18670648
has license	cc0
sha1sum (hex)	6ed1c5f102cce4bbcbd9d5438b6b8be3d4746484
schema:url	https://doi.org/10.1371/journal.ppat.1000115
resource representing a document's title	H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice
has PubMed Central identifier	PMC2483250
has PubMed identifier	18670648
schema:publication	PLoS Pathog
resource representing a document's body	covid:6ed1c5f102cce4bbcbd9d5438b6b8be3d4746484#body_text
is schema:about of	named entity '1918 pandemic influenza virus' named entity 'pulmonary edema' named entity 'human' named entity 'influenza' named entity 'macrophages' named entity 'Infiltration' covid:arg/6ed1c5f102cce4bbcbd9d5438b6b8be3d4746484 named entity 'compared' named entity 'infection' named entity 'human' named entity 'high' named entity 'rapid' named entity 'leads' named entity 'acute' named entity 'H5N1' named entity 'viruses' named entity 'infected' named entity 'virus' named entity 'H5N1' named entity 'mice' named entity 'lung' named entity 'infection' named entity 'H5N1' named entity 'pro-inflammatory cytokines' named entity 'H5N1' named entity 'neutrophils' named entity '1918 pandemic' named entity 'inflammatory infiltrate' named entity 'virus' named entity 'H5N1' named entity 'macrophages' named entity 'flow cytometry' named entity 'H5N1' named entity 'neutrophils' named entity 'macrophages' named entity 'influenza virus' named entity 'H1N1' named entity 'macrophages' named entity 'lung' named entity 'mice' named entity 'lung' named entity 'H5N1' named entity 'cellular' named entity 'leukocytes' named entity 'H1N1' named entity 'innate immune responses' named entity 'influenza infection' named entity 'infection' named entity 'lung tissue' named entity 'infection' named entity 'cytokine' named entity 'CD11b' named entity 'lungs' named entity 'trypan blue' named entity 'high levels' named entity 'acute lung injury' named entity 'viruses' named entity 'Macrophages' named entity 'Auburn, CA' named entity 'CD80' named entity 'statistically significant' named entity 'chemoattractant' named entity 'neutrophils' named entity 'Thailand' named entity 'staining' named entity 'CD11b+' named entity 'IL-1b' named entity 'virus replication' named entity 'dendritic cell' named entity 'chemokines' named entity 'viruses' named entity 'macrophages' named entity 'dendritic cells' named entity 'influenza virus' named entity 'Cytokine' named entity 'virus infection' named entity 'fluorophore'

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