About: Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells

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About: Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells
Creator	Zhang, Li Li, Yuanyuan Shi, Weifeng Sun, Jing Ji, Yun Jiang, Jingting Mao, Yijie Peng, Hongjun Shi, Mei Wang, Xiaohui Xu, Xiaopeng Zhang, Lirong Zhang, Xiaolei
source	Medline; PMC
abstract	BACKGROUND: c-Jun NH(2)-terminal kinase/stress-activated kinase (JNK/SAPK) and the p38 mitogen-activated protein kinase (p38 MAPK) are important components of cellular signal transduction pathways, which have been reported to be involved in viral replication. However, little is known about JNK1/2 and p38 MAPK signaling pathways in enterovirus 71 (EV71)-infected immature dendritic cells (iDCs). Thus, iDCs were induced from peripheral blood mononuclear cells (PBMC) and performed to explore the expressions and phosphorylation of molecules in the two signaling pathways as well as secretions of inflammatory cytokines and interferons during EV71 replication. RESULTS: We showed that EV71 infection could activate both JNK1/2 and p38 MAPK in iDCs and phosphorylate their downstream transcription factors c-Fos and c-Jun, which further promoted the production of IL-2, IL-6, IL-10, and TNF-α. Moreover, EV71 infection also increased the release of IFN-β and IL-12 p40. Pretreatment of iDCs with SP600125 and SB203580 (20 μM) could severely impair viral replication and its induced phosphorylation of JNK1/2,p38 MAPK, c-Fos and c-Jun. In addition, treatment of EV71-infected iDCs with SP600125 and SB203580 could inhibit secretions of IL-6, IL-10 and TNF-α. CONCLUSION: JNK1/2 and p38 MAPK signaling pathways are beneficial to EV71 infection and positively regulate secretions of inflammatory cytokines in iDCs.
has issue date	2014-06-07(xsd:dateTime)
bibo:doi	10.1186/1471-2180-14-147
bibo:pmid	24906853
has license	cc-by
sha1sum (hex)	6ebb0d128a1f03635f662f5419927c90c61855e5
schema:url	https://doi.org/10.1186/1471-2180-14-147
resource representing a document's title	Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells
has PubMed Central identifier	PMC4057572
has PubMed identifier	24906853
schema:publication	BMC Microbiol
resource representing a document's body	covid:6ebb0d128a1f03635f662f5419927c90c61855e5#body_text
is schema:about of	named entity 'induced' named entity 'transcription factors' named entity 'IL-6' named entity 'immature' named entity 'P38 MAPK SIGNALING' named entity 'JNK1' named entity 'KINASE' named entity 'SECRETIONS' named entity 'SB203580' named entity 'IL-2' named entity 'INFECTED' named entity 'HAVE' named entity 'BACKGROUND' named entity 'LITTLE' named entity 'JNK1' named entity 'SIGNAL TRANSDUCTION PATHWAYS' named entity 'ACTIVATION' named entity 'IMMATURE' named entity 'REPORTED' named entity 'P38 MITOGEN-ACTIVATED PROTEIN KINASE' named entity 'DOWNSTREAM' named entity 'IMPORTANT' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'MOLECULES' named entity 'DENDRITIC CELLS' named entity 'SIGNALING PATHWAYS' named entity 'ENTEROVIRUS 71' named entity 'INVOLVED' named entity 'THEIR' named entity 'CELLULAR SIGNAL TRANSDUCTION' named entity 'INCREASED' named entity 'REPLICATION' named entity 'PRODUCTION' named entity 'INFLAMMATORY' named entity 'C-FOS' named entity 'INTERFERONS' named entity 'KNOWN' named entity 'IDCS' named entity 'TREATMENT' named entity 'IFN' named entity 'RESULTS' named entity 'JUN.' named entity 'TERMINAL' named entity '10%' named entity 'IMMATURE' named entity 'ACTIVATE' named entity 'PHOSPHORYLATION' named entity 'SEVERELY' named entity 'INDUCED' named entity 'ADDITION' named entity 'INFECTION' named entity 'CYTOKINES' named entity 'P38 MAPK' named entity 'IL-12' named entity 'ABOUT' named entity 'VIRAL REPLICATION' named entity 'BCM' named entity 'MAPK' named entity 'C-JUN' named entity 'EXPRESSIONS' named entity 'DENDRITIC CELLS' named entity 'SIGNALING PATHWAYS' named entity 'ENTEROVIRUS 71 INFECTION' named entity 'IL-6' named entity 'PRETREATMENT' named entity 'ACTIVATED' named entity 'COMPONENTS' named entity 'P38 MAPK SIGNALING' named entity 'RELEASE'

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