About: Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence
Creator	Zhao, Hong Zhang, Yuan Loeb, Mark Garner, Paul Chen, Guang Alhazzani, Waleed Santesso, Nancy Med, Aston, Stephen Chen, ; Akl, Elie Bak, Anna Baldeh, Tejan Bognanni, Antonio Borowiack, Ewa Brignardello-Petersen, Romina Chamseddine, Fatimah Chu, Derek Cuello-Garcia, Carlos Darzi, Andrea El-Khoury, Rayane Hajizadeh, Anisa Harrison, Leila Hneiny, Layal Izcovich, Ariel Khabsa, Joanne Khamis, Assem Lotfi, Tamara Neumann, Ignacio Piggott, Thomas Reinap, Marge Rochwerg, Bram Saad, Zahra Solo, Karla Stalteri, Rosa Szczeklik, Wojciech Thomas, Rebecca Yaacoub, Sally Akl, Bou Amena El-Harakeh, Ddm Brozek, Jan Fan, ; Finn, ; Gian, ; Mats, Ma Morgano, Paolo Muti-Schü, Giovanna Nemann, Cand Nemann, Schü Nieuwlaat, Robby Perri, Dan Schmidt, Joel Schü Nemann, Holger Stehling, Florian
Source	Medline; PMC
abstract	BACKGROUND: Mechanical ventilation is used to treat respiratory failure in coronavirus disease 2019 (COVID-19). PURPOSE: To review multiple streams of evidence regarding the benefits and harms of ventilation techniques for coronavirus infections, including that causing COVID-19. (PROSPERO registration: CRD42020178187) DATA SOURCES: 21 standard, World Health Organization–specific and COVID-19–specific databases, without language restrictions, until 1 May 2020. STUDY SELECTION: Studies of any design and language comparing different oxygenation approaches in patients with coronavirus infections, including severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS), or with hypoxemic respiratory failure. Animal, mechanistic, laboratory, and preclinical evidence was gathered regarding aerosol dispersion of coronavirus. Studies evaluating risk for virus transmission to health care workers from aerosol-generating procedures (AGPs) were included. DATA EXTRACTION: Independent and duplicate screening, data abstraction, and risk of bias assessment (GRADE for certainty of evidence and AMSTAR 2 for included systematic reviews). DATA SYNTHESIS: 123 studies were eligible (45 on COVID-19, 70 on SARS, 8 on MERS), but only 5 studies (1 on COVID-19, 3 on SARS, 1 on MERS) adjusted for important confounders. A study in hospitalized patients with COVID-19 reported slightly higher mortality with noninvasive ventilation (NIV) than with invasive mechanical ventilation (IMV), but 2 opposing studies, 1 in patients with MERS and 1 in patients with SARS, suggest a reduction in mortality with NIV (very low-certainty evidence). Two studies in patients with SARS report a reduction in mortality with NIV compared with no mechanical ventilation (low-certainty evidence). Two systematic reviews suggest a large reduction in mortality with NIV compared with conventional oxygen therapy. Other included studies suggest increased odds of transmission from AGPs. LIMITATION: Direct studies in COVID-19 are limited and poorly reported. CONCLUSION: Indirect and low-certainty evidence suggests that use of NIV, similar to IMV, probably reduces mortality but may increase the risk for transmission of COVID-19 to health care workers. PRIMARY FUNDING SOURCE: World Health Organization.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.7326/m20-2306
bibo:pmid	32442035
has license	no-cc
sha1sum (hex)	6e584477ce99f333ec260958ba27cc5d164b7d11
schema:url	https://doi.org/10.7326/m20-2306
resource representing a document's title	Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence
has PubMed Central identifier	PMC7281716
has PubMed identifier	32442035
schema:publication	Ann Intern Med
resource representing a document's body	covid:6e584477ce99f333ec260958ba27cc5d164b7d11#body_text
is schema:about of	named entity 'Multiple' named entity 'COVID-19' named entity 'Systematic Review' named entity 'nasal cannula' named entity 'SARS' named entity 'MERS' named entity 'meta-analyses' named entity 'NIV' named entity 'intubation' named entity 'death rate' named entity 'Allen Institute' named entity 'COVID' named entity 'febrile' named entity 'COVID' named entity 'COVID' named entity 'anesthetists' named entity 'RCT' named entity 'AGPs' named entity 'SARS-CoV-1' named entity 'COVID' named entity 'GRADE' named entity 'randomized trials' named entity 'systematic reviews' named entity 'preclinical' named entity 'NIV' named entity 'aerosol' named entity 'NIV' named entity 'confounding'

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