About: Ferret models of viral pathogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ferret models of viral pathogenesis
Creator	Enkirch, T Von Messling, V
Source	Elsevier; Medline; PMC
abstract	Abstract Emerging and well-known viral diseases remain one the most important global public health threats. A better understanding of their pathogenesis and mechanisms of transmission requires animal models that accurately reproduce these aspects of the disease. Here we review the role of ferrets as an animal model for the pathogenesis of different respiratory viruses with an emphasis on influenza and paramyxoviruses. We will describe the anatomic and physiologic characteristics that contribute to the natural susceptibility of ferrets to these viruses, and provide an overview of the approaches available to analyze their immune responses. Recent insights gained using this model will be highlighted, including the development of new prophylactic and therapeutic approaches. To provide decision criteria for the use of this animal model, its strengths and limitations will be discussed.
has issue date	2015-05-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.03.017
bibo:pmid	25816764
has license	els-covid
sha1sum (hex)	6e49c916b5a03127c6af714fc505fa6fce312665
schema:url	https://doi.org/10.1016/j.virol.2015.03.017
resource representing a document's title	Ferret models of viral pathogenesis
has PubMed Central identifier	PMC7111696
has PubMed identifier	25816764
schema:publication	Virology
resource representing a document's body	covid:6e49c916b5a03127c6af714fc505fa6fce312665#body_text
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